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The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain
Publikováno v:
Biochim Biophys Acta Gen Subj
UBQLN proteins regulate proteostasis by facilitating clearance of misfolded proteins through the proteasome and autophagy degradation pathways. Consistent with its proteasomal function, UBQLN proteins contain both UBL and UBA domains, which bind subu
Autor:
Svetlana A. Kruglova, Vera V. Teplova, Irina Odinokova, Olga Krestinina, Ekaterina S. Kharechkina, Yulia Baburina, Anna B. Nikiforova, Alexey G. Kruglov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:771-783
Background The opening of the permeability transition pore (PTP) in mitochondria plays a critical role in the pathogenesis of numerous diseases. Mitochondrial matrix pyridine nucleotides are potent regulators of the PTP, but the role of extramitochon
Autor:
Yan Zhang, Yingjiao Xu, Feng Liu, Xing Li, Fang Yang, Aidong Shan, Takashi Sato, Zhijue Xu, Jishun Lu, Wei Li, Hisashi Narimatsu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:870-882
Mucin-type O-glycosylation plays important roles in various biological processes. It is initiated by a family of 20 conserved UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts). Unlike most ppGalNAc-Ts localized to the Golgi app
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:692-702
Background Hydrogen peroxide (H2O2) is thought to be one of the key components involved in the responses of tumor cells to chemotherapy. The aim of this study was to reveal the pathways and the phases of cisplatin-induced cell death that are characte
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:466-471
Background A healthy human can produce over 1 × 1015 blood cells throughout their life. This remarkable amount of biomass requires a concomitantly vast amount of iron to generate functional haemoglobin and functional erythrocytes. Scope of the revie
Autor:
Giovanna Musco, Chiara Zucchelli, Giacomo Quilici, Giuseppe Filosa, Angela Bachi, Michela Ghitti, Simone Tamburri
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:456-465
Background Human Sp140 protein is a leukocyte-specific member of the speckled protein (Sp) family (Sp100, Sp110, Sp140, Sp140L), a class of multi-domain nuclear proteins involved in intrinsic immunity and transcriptional regulation. Sp140 regulates m
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2605-2612
Background The abuse of opioids, such as morphine and phentanyl or other drugs as heroin is a social and health problem that affects an increasing number of people each year. The activation of the mu opioid receptor triggers several molecular changes
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2304-2313
Background Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a member of the Ca2+/calmodulin-dependent kinase (CaMK) family, functions as an upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase. Thus, CaMKK2 is involve
Autor:
Ran Cheng, Hidenori Ichijo, Tohru Natsume, Shun-ichiro Iemura, Kazuki Hattori, Tomohisa Hatta, Isao Naguro, Kohsuke Takeda
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2271-2280
Apoptosis signal-regulating kinase 1 (ASK1) is a key player in the homeostatic response of many organisms. Of the many functions of ASK1, it is most well-known for its ability to induce canonical caspase 3-dependent apoptosis through the MAPK pathway
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2031-2042
Background Nucleotide excision repair (NER) pathway is an evolutionarily conserved mechanism of genome maintenance. It detects and repairs distortions in DNA double helix. Xeroderma Pigmentosum group B (XPB) and group D (XPD) are important helicases