Zobrazeno 81 - 90
of 242
pro vyhledávání: ''
Autor:
Erik A. Richter, Elke Schaeffeler, Nils Kroeger, Kai Masur, Stefan Winter, Jörg Mostertz, Silvia Ribback, Liane Kantz, Falko Hochgräfe, Christopher Horst Lillig, Eva-Maria Hanschmann, Matthias Schwab, Manuela Gellert
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129599
Backround Cytosolic glutaredoxin 2 (Grx2c) controls axonal outgrowth and is specifically induced in many cancer cell lines. We thus hypothesized that Grx2c promotes cell motility and invasiveness. Methods We characterized the impact of Grx2c expressi
Autor:
Tetsuya Hirata, Misuzu Hashimoto, Yasuhiko Kizuka, Tsutomu Nakagawa, Akiyoshi Fukamizu, Chizuko Yonekawa, Kaho Takeichi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129509
Background Brains express structurally unique glycans, including human natural killer-1 (HNK-1), which participate in development and high-order functions. However, the regulatory mechanisms of expression of these brain-specific glycans are largely u
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1864(No. 2):129329
Background Cell-based assays are essential for analyzing molecular functions and spatiotemporal information. The cell resealing technique, in which pore-forming toxins are used to permeabilize cell membranes, enables the delivery of various membrane-
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129397
Background Yes-associated protein (YAP) is a key effector of the Hippo pathway and is frequently dysregulated in aggressive human cancers. Aberrant YAP activation has emerged as an important driver of tumorigenesis, chemoresistance and metastasis. Si
Autor:
Terence E. Hébert, Alain Fournier, Dominic Devost, Shunmoogum A. Patten, Myriam Létourneau, David Chatenet, Mathilde Poujol de Molliens, Priyanka Jamadagni
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:129398
Background The pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1), a class B G protein-coupled receptor (GPCR), has emerged as a promising target for treating neurodegenerative conditions. Unfortunately, despite years o
Autor:
Alexandra I. Baglay, G. V. Sharonov, Maria N. Balatskaya, Vsevolod A. Tkachuk, Yury P. Rubtsov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:129414
Background Unlike other cadherins, T-cadherin does not mediate strong cell-cell adhesion. It has two soluble ligands: low density lipoprotein (LDL) and high-molecular-weight (HMW) adiponectin. LDL binding to T-cadherin induces calcium signaling, migr
Autor:
Shu-ichi Okamoto, Stuart A. Lipton
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1588-1593
Nitric oxide (NO) is a pleiotropic messenger molecule. The multidimensional actions of NO species are, in part, mediated by their redox nature. Oxidative posttranslational modification of cysteine residues to regulate protein function, termed S-nitro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1607-1621
Background Within cells, there is a narrow concentration threshold that governs whether reactive oxygen species (ROS) induce toxicity or act as second messengers. Scope of review We discuss current understanding of how ROS arise, facilitate cell sign
Autor:
Irena Peri, Michael Naim, Merav E. Shaul, Liquan Huang, Rony Seger, Andrew I. Spielman, Einav Malach
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1375-1388
Background Amphipathic sweet and bitter tastants inhibit purified forms of the protein kinases GRK2, GRK5 and PKA activities. Here we tested whether membrane-permeable tastants may intracellularly interfere with GPCR desensitization at the whole cell
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1261-1266
Physical cues of cellular environment affect cell fate and differentiation. For example, an environment with high stiffness drives mesenchymal stem cells (MSCs) to undergo osteogenic differentiation, while low stiffness leads to lipogenic differentia