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The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain
Publikováno v:
Biochim Biophys Acta Gen Subj
UBQLN proteins regulate proteostasis by facilitating clearance of misfolded proteins through the proteasome and autophagy degradation pathways. Consistent with its proteasomal function, UBQLN proteins contain both UBL and UBA domains, which bind subu
Autor:
Giovanna Musco, Chiara Zucchelli, Giacomo Quilici, Giuseppe Filosa, Angela Bachi, Michela Ghitti, Simone Tamburri
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:456-465
Background Human Sp140 protein is a leukocyte-specific member of the speckled protein (Sp) family (Sp100, Sp110, Sp140, Sp140L), a class of multi-domain nuclear proteins involved in intrinsic immunity and transcriptional regulation. Sp140 regulates m
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2605-2612
Background The abuse of opioids, such as morphine and phentanyl or other drugs as heroin is a social and health problem that affects an increasing number of people each year. The activation of the mu opioid receptor triggers several molecular changes
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2304-2313
Background Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a member of the Ca2+/calmodulin-dependent kinase (CaMK) family, functions as an upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase. Thus, CaMKK2 is involve
Autor:
Caroline Smet-Nocca, Eleni Nikolakaki, Isabelle Landrieu, Adeline Page, François-Xavier Cantrelle, Thomas Giannakouros
Publikováno v:
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Lamin B Receptor (LBR) is an integral protein of the interphase inner nuclear membrane that is implicated in chromatin anchorage to the nuclear envelope. Phosphorylation of a stretch of arginine-serine (RS) dipeptides in the amino-terminal nucleoplas
Autor:
Jariya Sangthong, Fabien Loison, Kulthida Vaeteewoottacharn, Mathurose Ponglikitmongkol, Wareerat Umnajvijit
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129850
Background A splice product of the E6 oncoprotein, E6*, is found in cells infected with HPV associated with a high-risk for cervical cancer. Both E6* and E6 promote Dlg degradation, considered a contributing factor for the tumorigenic potential of hi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129829
Background Iron export via the transport protein ferroportin (Fpn) plays a critical role in the regulation of dietary iron absorption and iron recycling in macrophages. Fpn plasma membrane expression is controlled by the hepatic iron-regulated hormon
Autor:
Siro Simizu, Kazuki Miura, Takehiro Suzuki, Hongkai Sun, Naoshi Dohmae, Haruka Takada, Yudai Ishizawa, Hayato Mizuta
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129833
Background C-mannosylation is a unique type of glycosylation. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is a multidomain extracellular metalloproteinase that contains several potential C-mannosylation sites. Although
Autor:
Fabio Librizzi, Claudio Canale, Fabio Bucchieri, Silvia Vilasi, Rosa Passantino, Dario Spigolon, Maria Rosalia Mangione, Pier Luigi San Biagio, Claudia Marino, Donatella Bulone, Francesco Cappello, Alberto Fucarino
Publikováno v:
Biochimica et biophysica acta. G, General subjects
1860 (2016): 2474–2483. doi:10.1016/j.bbagen.2016.07.019
info:cnr-pdr/source/autori:Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL/titolo:Hsp60, amateur chaperone in amyloid-beta fibrillogenesis/doi:10.1016%2Fj.bbagen.2016.07.019/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2016/pagina_da:2474/pagina_a:2483/intervallo_pagine:2474–2483/volume:1860
1860 (2016): 2474–2483. doi:10.1016/j.bbagen.2016.07.019
info:cnr-pdr/source/autori:Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL/titolo:Hsp60, amateur chaperone in amyloid-beta fibrillogenesis/doi:10.1016%2Fj.bbagen.2016.07.019/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2016/pagina_da:2474/pagina_a:2483/intervallo_pagine:2474–2483/volume:1860
BACKGROUND: Molecular chaperones are a very special class of proteins that play essential roles in many cellular processes like folding, targeting and transport of proteins. Moreover, recent evidence indicates that chaperones can act as potentially s
Autor:
Alexia Borgeat, Inês De Magalhaes Pinheiro, Kalyana Bharati Akondi, Oliver Hartley, Ilaria Scurci, Marianne Paolini-Bertrand, Fabrice Cerini
Publikováno v:
Biochimica et Biophysica Acta-General Subjects, Vol. 1865, No 1 (2020) P. 129753
Background Chemokine receptor tyrosine sulfation plays a key role in the binding of chemokines. It has been suggested that receptor sulfation is heterogeneous, but no experimental evidence has been provided so far. The potent anti-HIV chemokine analo