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Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2605-2612
Background The abuse of opioids, such as morphine and phentanyl or other drugs as heroin is a social and health problem that affects an increasing number of people each year. The activation of the mu opioid receptor triggers several molecular changes
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2304-2313
Background Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a member of the Ca2+/calmodulin-dependent kinase (CaMK) family, functions as an upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase. Thus, CaMKK2 is involve
Autor:
Caroline Smet-Nocca, Eleni Nikolakaki, Isabelle Landrieu, Adeline Page, François-Xavier Cantrelle, Thomas Giannakouros
Publikováno v:
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩
Lamin B Receptor (LBR) is an integral protein of the interphase inner nuclear membrane that is implicated in chromatin anchorage to the nuclear envelope. Phosphorylation of a stretch of arginine-serine (RS) dipeptides in the amino-terminal nucleoplas
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2515-2529
Background Annexin A2 (AnxA2) is a multifunctional protein involved in endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal transduction, protein assembly, transcription and mRNA transport, as well as DNA replication and r
Autor:
J. Silvio Gutkind, Federico Monczor, Natalia Fernández, Antonela Díaz Nebreda, Carina Shayo, Natalia Alonso, Carlos Davio
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1998-2007
Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Many evidences have demonstrated the existence and importance of the crossregulation bet
Publikováno v:
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2020, 1864, pp.129705-. ⟨10.1016/j.bbagen.2020.129705⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2020, 1864, pp.129705-. ⟨10.1016/j.bbagen.2020.129705⟩
Background DNA dependent Protein Kinase (DNA-PK) is an heterotrimeric complex regulating the Non Homologous End Joining (NHEJ) double strand break (DSB) repair pathway. The activity of its catalytic subunit (DNA-PKcs) is regulated by multiple phospho
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1551-1559
Background Dermal fibroblasts activated by conductive polymer-mediated electrical stimulation (ES) have shown myofibroblast characteristics that favor wound healing. However, the signaling pathway related to this phenotype switch remains unclear, and
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:167-182
Background αB-crystallin, once thought to be a lenticular protein, is ubiquitous and has critical roles in several cellular processes that are modulated by phosphorylation. Serine residues 19, 45 and 59 of αB-crystallin undergo phosphorylation. Pho
Ankyrin exposure induced by activated protein kinase C plays a potential role in erythrophagocytosis
Autor:
Dong Chen, Fuzhou Tang, Yang Ren, Yajin Zhao, Ruofeng Wang, Xueru Deng, Xiaofeng Lei, Xiang Wang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:120-128
Background In physiological and pathological conditions activated protein kinace C (PKC) has been observed in the erythrocytes. Externalization of ankyrin followed by Arg–Gly–Asp (RGD)/integrin recognition also triggers erythrophagocytosis. In th
Autor:
Irena Peri, Michael Naim, Merav E. Shaul, Liquan Huang, Rony Seger, Andrew I. Spielman, Einav Malach
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1375-1388
Background Amphipathic sweet and bitter tastants inhibit purified forms of the protein kinases GRK2, GRK5 and PKA activities. Here we tested whether membrane-permeable tastants may intracellularly interfere with GPCR desensitization at the whole cell