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Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:466-471
Background A healthy human can produce over 1 × 1015 blood cells throughout their life. This remarkable amount of biomass requires a concomitantly vast amount of iron to generate functional haemoglobin and functional erythrocytes. Scope of the revie
Autor:
Koji Yamano, Waka Kojima
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129972
Background Perturbations in organellar health can lead to an accumulation of unwanted and/or damaged organelles that are toxic to the cell and which can contribute to the onset of neurodegenerative diseases such as Parkinson's disease. Mitochondrial
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129975
Introduction The endothelial glycocalyx is susceptible to high concentration of glucose and sodium in the blood. These challenges often involve an increase in osmotic pressure which may independently alters the glycocalyx components. The glycocalyx a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2274-2281
Background Cytochrome c is well known to be released from mitochondria into the cytosol where it can initiate apoptosis. Recent studies indicate that cytochrome c is also released into the extracellular space by both healthy and damaged cells, where
Autor:
Norifumi Kawada, Hiroshi Tanaka, Ken Oofusa, Katsutoshi Yoshizato, Hiroaki Adachi, Satoru Nakata, Natsumi Saito
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2261-2273
Background Tensioned collagen gels with dermal fibroblasts (DFs) as a dermis model are usually utilized in a static culture (SC) that lacks medium flowing. To make the model closer to its in vivo state, we created a device to perfuse the model with m
Autor:
Swagatika Paul, Alicia M. Pickrell
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129871
PINK1, a serine/threonine ubiquitin kinase, and Parkin, an E3 ubiquitin ligase, work in coordination to target damaged mitochondria to the lysosome in a process called mitophagy. This review will cover what we have learned from PINK1 and Parkin knock
Autor:
Navjot Shah, Masaaki Ishii, M. Cristina Kenney, Crystal Nicholson, Balasubramaniam Annamalai, Marilyn Chwa, Kyrie Chandler, Bärbel Rohrer
Publikováno v:
Biochimica et biophysica acta. General subjects, vol 1865, iss 4
Biochim Biophys Acta Gen Subj
Biochim Biophys Acta Gen Subj
Purpose Extracellular vesicles (EVs) are predicted to represent the internal state of cells. In polarized RPE monolayers, EVs can mediate long-distance communication, requiring endocytosis via protein-protein interactions. EV uptake from oxidatively
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1877-1883
Non-invasive real time methods for characterizing biomolecular events that contribute towards apoptotic kinetics would be of significant importance in the field of cancer biology. Effective drug-induced apoptosis is an important factor for establishi
Autor:
Punit Kaur, Sunita Jhuria, Saroj Kumar, Manoj Kumar, Abdul S. Ethayathulla, Lakshay Malhotra, Kapil Dev, Harsh K.V. Goyal
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129807
Background The p53, tumor suppressor protein is inactivated upon mutation in the DNA-binding domain and the non-functional protein leads to cancers. The p53Y220C is one of the most frequently observed mutations in p53 with a scope of rescuing the pro
Publikováno v:
Biochim Biophys Acta Gen Subj
BACKGROUND: Organic anion transporter 1 (OAT1) plays a vital role in avoiding the potential toxicity of various anionic drugs through the involvement of kidney elimination. We previously demonstrated that ubiquitin conjugation to OAT1 led to OAT1 int