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Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:692-702
Background Hydrogen peroxide (H2O2) is thought to be one of the key components involved in the responses of tumor cells to chemotherapy. The aim of this study was to reveal the pathways and the phases of cisplatin-induced cell death that are characte
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:466-471
Background A healthy human can produce over 1 × 1015 blood cells throughout their life. This remarkable amount of biomass requires a concomitantly vast amount of iron to generate functional haemoglobin and functional erythrocytes. Scope of the revie
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2605-2612
Background The abuse of opioids, such as morphine and phentanyl or other drugs as heroin is a social and health problem that affects an increasing number of people each year. The activation of the mu opioid receptor triggers several molecular changes
Autor:
Ran Cheng, Hidenori Ichijo, Tohru Natsume, Shun-ichiro Iemura, Kazuki Hattori, Tomohisa Hatta, Isao Naguro, Kohsuke Takeda
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2271-2280
Apoptosis signal-regulating kinase 1 (ASK1) is a key player in the homeostatic response of many organisms. Of the many functions of ASK1, it is most well-known for its ability to induce canonical caspase 3-dependent apoptosis through the MAPK pathway
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2031-2042
Background Nucleotide excision repair (NER) pathway is an evolutionarily conserved mechanism of genome maintenance. It detects and repairs distortions in DNA double helix. Xeroderma Pigmentosum group B (XPB) and group D (XPD) are important helicases
Autor:
Koji Yamano, Waka Kojima
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129972
Background Perturbations in organellar health can lead to an accumulation of unwanted and/or damaged organelles that are toxic to the cell and which can contribute to the onset of neurodegenerative diseases such as Parkinson's disease. Mitochondrial
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129975
Introduction The endothelial glycocalyx is susceptible to high concentration of glucose and sodium in the blood. These challenges often involve an increase in osmotic pressure which may independently alters the glycocalyx components. The glycocalyx a
Autor:
Rohan Dhiman, Saqib Kidwai, Shradha Mawatwal, Sakshi Agarwal, Assirbad Behura, Abhirupa Ghosh, Amar Deep, Abtar Mishra, Sudipto Saha, Ramandeep Singh
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:3190-3200
Phenotypic screening led to the identification of calcimycin as a potent inhibitor of Mycobacterium bovis BCG (M. bovis BCG) growth in vitro and in THP-1 cells. In the present study, we aim to decipher the mechanism of antimycobacterial activity of c
Autor:
Koichi Furukawa, Pu Zhang, Robiul H. Bhuiyan, Noboru Hashimoto, Yuhsuke Ohmi, Yuki Ohkawa, Shuting Ji, Orie Tajima, Keiko Furukawa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2479-2484
Gene knockout mice of glycosyltransferases have clearly showed roles of their products in the bodies, while there are examples where phenotype of knockout was much less severe than expected probably due to functional redundancy. The most striking nov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2274-2281
Background Cytochrome c is well known to be released from mitochondria into the cytosol where it can initiate apoptosis. Recent studies indicate that cytochrome c is also released into the extracellular space by both healthy and damaged cells, where