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Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:692-702
Background Hydrogen peroxide (H2O2) is thought to be one of the key components involved in the responses of tumor cells to chemotherapy. The aim of this study was to reveal the pathways and the phases of cisplatin-induced cell death that are characte
Autor:
Daniel J. Klionsky, Yuxiang J. Huang
Publikováno v:
Biochim Biophys Acta Gen Subj
Superfluous and damaged mitochondria need to be efficiently repaired or removed. Mitophagy is a selective type of autophagy that can engulf a portion of mitochondria within a double-membrane structure, called a mitophagosome, and deliver it to the va
Autor:
Taeko Sasaki, Miyuki Sato
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129886
Background In most sexually reproducing organisms, mitochondrial DNA (mtDNA) is inherited maternally. Scope of review In this review, we summarise recent knowledge on how paternal mitochondria and their mtDNA are selectively eliminated from embryos.
Autor:
Nitu Kumari, Sathees C. Raghavan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129857
Background DNA, the genetic material of most of the organisms, is the crucial element of life. Integrity of DNA needs to be maintained for transmission of genetic material from one generation to another. All organisms are constantly challenged by the
Autor:
Marina Ziche, Claudio Rossi, Gemma Leone, Cinzia Della Giovampaola, Antonietta Capone, Federica Finetti, Floriana Rosati, Sandra Donnini, Pietro Lupetti, Claudia Bonechi, Agnese Magnani, Leonardo Ermini, Elisa Vannuccini
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:860-870
Background Liposomes, used to improve the therapeutic index of new and established drugs, have advanced with the insertion of active targeting. The lectin from Lotus tetragonolobus (LTL), which binds glycans containing alpha-1,2-linked fucose, reveal
Autor:
Ana P.M. Ramos, Beate S. Santos, Maria I.A. Pereira, Paulo E. Cabral Filho, Ana L. Cardoso, Adriana Fontes, Carlos F. G. C. Geraldes, Fernando Hallwass, Maria C. Pedroso de Lima, M. Margarida C. A. Castro, Giovannia A. L. Pereira
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:28-35
Background Overexpression of transferrin receptors (TfRs), which are responsible for the intracellular uptake of ferric transferrin (Tf), has been described in various cancers. Although molecular biology methods allow the identification of different
Autor:
Elena V. Zagaynova, Varvara V. Dudenkova, Vsevolod V. Belousov, Maria M. Lukina, Sergey Lukyanov, Ludmila B. Snopova, Irina N. Druzhkova, Mikhail E. Matlashov, Natalia N. Prodanetz, Marina V. Shirmanova
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1905-1911
Background Measuring intracellular pH (pHi) in tumors is essential for the monitoring of cancer progression and the response of cancer cells to various treatments. The purpose of the study was to develop a method for pHi mapping in living cancer cell
Autor:
Sergey Lukyanov, Natalia V. Klementieva, Boris E. Shakhov, Nadezhda I. Ignatova, Elena V. Zagaynova, Marina V. Shirmanova, Ludmila B. Snopova, Alina P. Ryumina, Ilya V. Turchin, Arkady F. Fradkov, Maria M. Kuznetsova, Konstantin A. Lukyanov, Ekaterina O. Serebrovskaya
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1830:5059-5067
Background Genetically encoded photosensitizers are a promising optogenetic instrument for light-induced production of reactive oxygen species in desired locations within cells in vitro or whole body in vivo. Only two such photosensitizers are curren
Autor:
Alessio Ferrone, Emanuela Ricciotti, Sara Franceschelli, Antonia Patruno, Marialuigia Fantacuzzi, Maria Anna De Lutiis, Lorenza Speranza, Rosa Amoroso, Mario Felaco, Cristina Maccallini, Mirko Pesce
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1820:2095-2104
Background Previous reports suggest that NO may contribute to the pathophysiology of septic shock. Recently, we have synthesized and characterized a series of benzyl- and dibenzyl derivative of N -(3-aminobenzyl)acetamidine, a potent and selective in
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:1075-1083
Long-lived mutants provide unique insights into the genetic factors that limit lifespan in wild-type animals. Most mutants and RNA-interference targets found to extend life, typically by 1.5- to 2.5-fold, were discovered in C. elegans. Several longev