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The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production
Autor:
Kai Wang, Ronghua Zhang, Ke Xu, Wei Lv, Wolfgang Schwarz, Sidong Xiong, Wenjing Yu, Bing Sun, Shiqi Xie
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
In addition to a set of canonical genes, coronaviruses encode additional accessory proteins. A locus located between the spike and envelope genes is conserved in all coronaviruses and contains a complete or truncated open reading frame (ORF). Previou
Autor:
Melissa Romeo, Angela Regina, Susie Boydston-White, Tatyana Chernenko, Miloš Miljković, Max Diem
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (7):908-914
We have previously reported spectral differences for cells at different stages of the eukaryotic cell division cycle. These differences are due to the drastic biochemical and morphological changes that occur as a consequence of cell proliferation. We
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):579-588
Cells undergo dynamic remodeling of the cytoskeleton during adhesion and migration on various extracellular matrix (ECM) substrates in response to physiological and pathological cues. The major mediators of such cellular responses are the heterodimer
Autor:
Helen M. Becker, Elangovan Gopal, Vadivel Ganapathy, Sudha Ananth, Carsten A. Wagner, Nagavedi S. Umapathy, Jaya P. Gnana-Prakasam, Puttur D. Prasad, Pamela M. Martin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (11):2690-2697
Recently, we cloned two Na+-coupled lactate transporters from mouse kidney, a high-affinity transporter (SMCT1 or slc5a8) and a low-affinity transporter (SMCT2 or slc5a12). Here we report on the cloning and functional characterization of human SMCT2
Autor:
Henry M. Colecraft, Tingting Yang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (7):1644-1654
RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members - Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (4):1091-1099
Genetically encoded FRET glucose nanosensors have proven to be useful for imaging glucose flux in HepG2 cells. However, the dynamic range of the original sensor was limited and thus it did not appear optimal for high throughput screening of siRNA pop
Autor:
Ashley O. Warcup, Jennifer Nelson, Michael Streeter, Katalyn R. Pickett, John D. Bell, Allan M. Judd, Elizabeth Gibbons
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):887-895
Secretory phospholipase A2 exhibits much greater activity toward apoptotic versus healthy cells. Various plasma membrane changes responsible for this phenomenon have been proposed, including biophysical alterations described as “membrane fluidity
Autor:
Silvia Vaena de Avalos, Jacek Bielawski, Hiroshi Kitagaki, Sergei A. Novgorodov, Youssef H. Zeidan, L. Ashley Cowart, Lina M. Obeid, Nabil Matmati, Yusuf A. Hannun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (11):2849-2861
The Saccharomyces cerevisiae inositol sphingolipid phospholipase C (Isc1p), a homolog of mammalian neutral sphingomyelinases, hydrolyzes complex sphingolipids to produce ceramide in vitro. Epitope-tagged Isc1p associates with the mitochondria in the
Autor:
Javier L. Baylon, Emad Tajkhorshid, Aditi Das, Yelena V. Grinkova, Jared A. Hammernik, Daryl D. Meling, Daniel R. McDougle, Amogh Kambalyal
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (10):2460-2470
CYP2J2 epoxygenase is an extrahepatic, membrane bound cytochrome P450 (CYP) that is primarily found in the heart and mediates endogenous fatty acid metabolism. CYP2J2 interacts with membranes through an N-terminal anchor and various non-contiguous hy
Autor:
Richard M. Epand, Gowtham Jayakumaran, Matthew K. Topham, Januvi Jegatheswaran, Arpita Gantayet
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (4):1050-1053
Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of