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Autor:
Gail D. Zeevalk, Alpa H. Gautam
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (7):819-828
Loss of dopamine (DA) homeostasis may be a contributing factor to cell damage in Parkinson's disease (PD). Past studies showing deleterious effects of DA on mitochondrial function, however, have been inconsistent raising questions about mitochondria
Autor:
Rodney L. Burton, Klaus Schulten, Antony R. Crofts, Doreen Victoria, Charles M. Wilson, Christopher B. Harrison, Sangjin Hong
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11-12):1362-1377
1. Recent results suggest that the major flux is carried by a monomeric function, not by an intermonomer electron flow. 2. The bifurcated reaction at the Qo-site involves sequential partial processes, - a rate limiting first electron transfer generat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (6-7):939-944
Coupled rat heart mitochondria produce externally hydrogen peroxide at the rates which correspond to about 0.8 and 0.3% of the total oxygen consumption at State 4 with succinate and glutamate plus malate as the respiratory substrates, respectively. S
Autor:
John Whitmarsh, Hong Li, Ladislav Nedbal, Govindjee, Louis A. Sherman, Qing Jun Wang, Abhay K. Singh
Publikováno v:
Biochim Biophys Acta
Oxygenic photosynthesis in cyanobacteria, algae, and plants requires photosystem II (PSII) to extract electrons from H(2)O and depends on photosystem I (PSI) to reduce NADP(+). Here we demonstrate that mixotrophically-grown mutants of the cyanobacter
Autor:
David G. Nicholls
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1416-1424
The ability of isolated brain mitochondria to accumulate, store and release calcium has been extensively characterized. Extrapolation to the intact neuron led to predictions that the in situ mitochondria would reversibly accumulate Ca(2+) when the co
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (1):98-108
Cytochrome c oxidase is the terminal enzyme in the electron transfer chain. It reduces oxygen to water and harnesses the released energy to translocate protons across the inner mitochondrial membrane. The mechanism by which the oxygen chemistry is co
Autor:
Michelle A. Yu, Tsuyoshi Egawa, Myat T. Lin, Syun Ru Yeh, Denis L. Rousseau, Jonathan P. Hosler, Krithika Ganesan, Robert B. Gennis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (10):1342-1348
Both the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides (RsCcO(aa3)) and the closely related bo(3)-type ubiquinol oxidase from Escherichia coli (EcQO(bo3)) possess a proton-conducting D-channel that terminates at a glutamic acid, E286,
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (8-9):938-948
While iron is often a limiting nutrient to Biology, when the element is found in the form of heme cofactors (iron protoporphyrin IX), living systems have excelled at modifying and tailoring the chemistry of the metal. In the context of proteins and e
Autor:
Lawrence I. Grossman, Icksoo Lee, Jenney Liu, Lobelia Samavati, Rabia Ramzan, Christopher Sinkler, Sebastian Vogt, Katrin Marcus, Maik Hüttemann, Gargi Mahapatra, Jeffrey W. Doan, Ashwathy Varughese, Thomas H. Sanderson, Stefan Helling, Guorong Lu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (4):598-609
Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water. This irreversible step is highly regulated, as indicated by the presence of tissu
Autor:
Dennis R. Winge, Hyung J. Kim
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (5):627-636
The Succinate Dehydrogenase (SDH) heterotetrameric complex catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and in the aerobic respiratory chains of eukaryotes and bacteria. Essential in this catalysis is the cov