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Autor:
Gail D. Zeevalk, Alpa H. Gautam
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (7):819-828
Loss of dopamine (DA) homeostasis may be a contributing factor to cell damage in Parkinson's disease (PD). Past studies showing deleterious effects of DA on mitochondrial function, however, have been inconsistent raising questions about mitochondria
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (6-7):939-944
Coupled rat heart mitochondria produce externally hydrogen peroxide at the rates which correspond to about 0.8 and 0.3% of the total oxygen consumption at State 4 with succinate and glutamate plus malate as the respiratory substrates, respectively. S
Autor:
David G. Nicholls
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1416-1424
The ability of isolated brain mitochondria to accumulate, store and release calcium has been extensively characterized. Extrapolation to the intact neuron led to predictions that the in situ mitochondria would reversibly accumulate Ca(2+) when the co
Autor:
Lawrence I. Grossman, Icksoo Lee, Jenney Liu, Lobelia Samavati, Rabia Ramzan, Christopher Sinkler, Sebastian Vogt, Katrin Marcus, Maik Hüttemann, Gargi Mahapatra, Jeffrey W. Doan, Ashwathy Varughese, Thomas H. Sanderson, Stefan Helling, Guorong Lu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (4):598-609
Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water. This irreversible step is highly regulated, as indicated by the presence of tissu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (1):150-156
Voltage-dependent anion channel (VDAC) is an abundant mitochondrial outer membrane protein. In mammals, three VDAC isoforms have been characterized. We have previously reported alterations in the function of mitochondria when assessed in situ in diff
Autor:
Keith Kerstann, Deborah G. Murdock, Vaidya Subramaniam, Pawel Golik, Goarik A. Melkonian, Pinar Coskun, Douglas C. Wallace, Shawn Levy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (7-8):666-675
Genetic inactivation of the nuclear-encoded mitochondrial heart-muscle adenine nucleotide translocator-1 (ANT1), which exports mitochondrial ATP to the cytosol in both humans (ANT1−/−) and mice (Ant1−/−), results in lactic acidosis and mitoch
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (9):1092-1097
The mitochondrial life cycle consists of frequent fusion and fission events. Ample experimental and clinical data demonstrate that inhibition of either fusion or fission results in deterioration of mitochondrial bioenergetics. While fusion may benefi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (5):491-502
Mitochondria-derived oxygen-free radical(s) are important mediators of oxidative cellular injury. It is widely hypothesized that excess NO enhances O 2 •− generated by mitochondria under certain pathological conditions. In the mitochondrial elect
Autor:
Antoni Barrientos, Andrea Ruetenik
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1434-1447
Dietary restriction (DR) attenuates many detrimental effects of aging and consequently promotes health and increases longevity across organisms. While over the last 15 years extensive research has been devoted towards understanding the biology of agi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (2):285-295
Protein thiolation by glutathione is a reversible and regulated post-translational modification that is increased in response to oxidants and nitric oxide. Because many mitochondrial enzymes contain critical thiol residues, it has been hypothesized t