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Publikováno v:
Biochimica et biophysica acta. 1860(11 Pt)
Methods 8-week-age male ApoE−/− mice were fed with the atherogenic diet together with or without tested compounds (rosuvastatin calcium, α-LNA-LMWCS, LMWCS and α-LNA) for 16 weeks. When the animals were killed, blood plasma was isolated to test
Autor:
Dimitri Fishman, Michal Hersfinkel, Yaki Caspi, Shaya Lev, Alexander M. Binshtok, Iulia I. Nita, Israel Sekler, Sagi Gudes
Publikováno v:
Biochimica et biophysica acta. 1863(12)
The nociceptive noxious heat-activated receptor - TRPV1, conducts calcium and sodium, thus producing a depolarizing receptor potential, leading to activation of nociceptive neurons. TRPV1-mediated calcium and sodium influx is negatively modulated by
Autor:
Catherine E. van Engen, Eveline Verheij, Inge M. E. Dijkstra, Mathieu Barbier, Jennifer Varin, Ronald J.A. Wanders, Stephan Kemp, Tessa H. Jacobs van Goethem, Michel Vidaud, Rob Ofman, Patrick Aubourg
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1862(10), 1861-1870. Elsevier
X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder caused by the accumulation of very long-chain fatty acids (VLCFA) due to mutations in the ABCD1 gene. The phenotypic spectrum ranges from a fatal cerebral demyelinating diseas
Autor:
Raffaele Maletta, Paolina Crocco, Giuseppina Rose, Giuseppe Passarino, Amalia C. Bruni, Miranda S. C. Wilson, Adolfo Saiardi
Publikováno v:
Biochimica et biophysica acta. 1862(9)
Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders, in
Autor:
Carolina Fischinger Moura de Souza, Caroline Paula Mescka, Carlos Eduardo Diaz Jacques, Maira Graeff Burin, Bruna Donida, Roberto Giugliani, Daiane Rodrigues, Carmen Regla Vargas, Fernanda Hendges de Bitencourt, Desirèe Padilha Marchetti
Publikováno v:
Biochimica et biophysica acta. 1862(9)
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disease caused by a deficient activity of iduronate-2-sulfatase, leading to abnormal accumulation of glycosaminoglycans (GAG). The main treatment for MPS II is enzyme replacement therapy (
Autor:
Reinhard E Friedrich, Michaela Schweizer, Till Koehne, Sandra Markmann, Bärbel Kahl-Nieke, Nicole Muschol, Christian Hagel, Markus Glatzel, Thorsten Schinke, Michael Amling, Thomas Braulke
Publikováno v:
Biochimica et biophysica acta. 1862(9)
Mucolipidosis II (MLII) is a severe systemic genetic disorder caused by defects in mannose 6-phosphate-dependent targeting of multiple lysosomal hydrolases and subsequent lysosomal accumulation of non-degraded material. MLII patients exhibit marked f
Publikováno v:
Biochimica et biophysica acta. 1860(8)
Background Understanding of the significance of posttranslational glycosylation in Alzheimer's disease (AD) is of growing importance for the investigation of the pathogenesis of AD as well as discovery research of the disease-specific serum biomarker
Autor:
Guoheng Xu, Xianjuan Lin, Jinghui Fan, Jichun Yang, Yongliang Feng, Xiao-Qin Shi, Chaoshu Tang, Qinghua Cui, Junyan Cai, Huamin Wang, Bin Geng
Publikováno v:
Biochimica et biophysica acta. 1861(5)
Adipocytes express the cystathionine γ lyase (CSE)-hydrogen sulfide (H2S) system. CSE-H2S promotes adipogenesis but ameliorates adipocyte insulin resistance. We investigated the mechanism of how CSE-H2S induces these paradoxical effects. First, we c
Autor:
Tatsuya Morimoto, Hidetoshi Suzuki, Yoichi Sunagawa, Koji Hasegawa, Masafumi Funamoto, Yasufumi Katanasaka, Yusuke Miyazaki, Hiromichi Wada
Publikováno v:
Biochimica et biophysica acta. 1862(9)
The zinc finger protein GATA4 is a transcription factor involved in cardiomyocyte hypertrophy. It forms a functional complex with the intrinsic histone acetyltransferase (HAT) p300. The HAT activity of p300 is required for the acetylation and transcr
Autor:
Jiliang Wang, Gerd Schmitz, Gerhard Liebisch, Xiuling Deng, Tanyarath Utaipan, Wolfgang Stremmel, Sabine Tuma-Kellner, Li Jiao, Walee Chamulitrat
Publikováno v:
Biochimica et biophysica acta. 1861(5)
PLA2G6 or GVIA calcium-independent PLA2 (iPLA2β) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy. iPLA2β is known to play a house-keeping role in phospholipid metabolism and remodeling. Howev