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Publikováno v:
Biochimica et biophysica acta. 1823(4)
This study demonstrated that exchange proteins directly activated by cAMP (Epac) and protein kinase A (PKA) by 8-bromo (8-Br)-adenosine 3′,5′-cyclic monophosphate (cAMP) stimulated [14C]-α-methyl-D-glucopyranoside (α-MG) uptake through increase
Autor:
Maria Norlin, Johan Lundqvist
Publikováno v:
Biochimica et biophysica acta. 1821(7)
The widely expressed steroid hydroxylase CYP7B1 is involved in metabolism of a number of steroids reported to influence estrogen and androgen signaling. Several studies by us and other investigators have linked this enzyme to effects on estrogen rece
Publikováno v:
Biochimica et biophysica acta. 1822(3)
Aging is associated with appearance of white matter hyperintensities (WMH) on MRI scans. Vascular risk and inflammation, which increase with age, may contribute to white matter deterioration and proliferation of WMH. We investigated whether circulati
Publikováno v:
Biochimica et biophysica acta. 1823(2)
It has been known that the inhibition of mitochondrial cytochrome c oxidase is one of the earliest events occurring under hypoxia and this inhibition can lead to neuronal damages. Thus, the cytochrome c oxidase inhibitor sodium cyanide (NaCN) is wide
Publikováno v:
Biochimica et biophysica acta. 1820(2)
Background The aim of this work was to evaluate the hepatoprotective ability of allopurinol to prevent the liver injury induced by carbon tetrachloride (CCl 4 ). Methods Acute liver damage was induced with CCl 4 (4 g/kg, by gavage); allopurinol (50 m
Autor:
Margarete Mehrabian, Eric Paul, Peter Langfelder, Steve Horvath, Aldons J. Lusis, Richard C. Davis, Zhiqiang Zhou, Lawrence W. Castellani, Eric E. Schadt
Publikováno v:
Biochimica et biophysica acta. 1821(3)
We report a systems genetic analysis of high density lipoprotein (HDL) levels in an F2 intercross between inbred strains CAST/EiJ and C57BL/6J. We previously showed that there are dramatic differences in HDL metabolism in a cross between these strain
Publikováno v:
Biochimica et biophysica acta. 1810(12)
Background Activation of adenylyl cyclase (AC) by prolonged exposure of mammalian organism to morphine was demonstrated in previous studies of mechanism of action of this drug. However, expression level of individual AC isoforms was not analyzed in c
Publikováno v:
Biochimica et biophysica acta. 1820(10)
Background Neurotransmitter levels are best measured in the cerebrospinal fluid (CSF), but that requires an invasive procedure. Methods Samples were collected from humans and rats. Eighteen women age 38–51 years with fibromyalgia provided samples o
Publikováno v:
Biochimica et biophysica acta. 1820(5)
Background Mitochondrial dysfunction is a prominent feature of neurodegenerative diseases including Parkinson's disease (PD), in which insulin signaling pathway may also be implicated because 50–80% of PD patients exhibited metabolic syndrome and i
Publikováno v:
Biochimica et biophysica acta. 1811(12)
Sebaceous glands secrete sebum onto the skin surface in a holocrine manner and as such a thin lipid layer is formed as a physiological barrier. In the present study, extracellular level of triacylglycerols (TG), a major sebum component, as well as in