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Autor:
Masateru Yamada, Hiroshi Yaginuma, Kousei Tsuyuki, Gaku Ichinowatari, Kazuo Ohuchi, Atsuo Tanimoto
Publikováno v:
Biochimica et biophysica acta. 1583(1)
As we had found previously that thapsigargin, an endomembrane Ca2+-ATPase inhibitor, induces production of intracellular platelet-activating factor (PAF) [Br. J. Pharmacol. 116 (1995) 2141], we decided to investigate the possible roles of intracellul
Autor:
Seyed Moein Moghimi
Publikováno v:
Biochimica et biophysica acta. 1590(1-3)
A two-step approach is described to chemically camouflage the inert surface of model polystyrene nanospheres of 60 nm in diameter against recognition by the body's defenses. The first step was based on the strong protein adsorbing potency of polystyr
Autor:
Graziella Allegri, Laura Caparrotta, Eugenio Ragazzi, Antonella Bertazzo, Carlo Virgilio Luigi Costa, M. Biasiolo
Publikováno v:
Biochimica et biophysica acta. 1571(1)
Recent data from our laboratory have indicated that the rabbit is a suitable animal model for the study of enzyme activities of the tryptophan-nicotinic acid pathway. We report here the pattern of tryptophan metabolism in rabbits made diabetic with a
Publikováno v:
Biochimica et biophysica acta. 1581(3)
A rapid in vitro assay was developed for monitoring protein-mediated cholesterol monomerization from bile acid aggregates. This assay uses a fluorescent cholesterol analog, 22-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-23,24-bisnor-5-cholen-3 beta-
Publikováno v:
Biochimica et biophysica acta. 1587(1)
The influence of aging on the mechanisms of liver injury and regeneration was studied in a model of hepatotoxicity induced in 2-, 6-, 12-, 18- and 30-month-old rats by a sublethal dose of thioacetamide (500 mg/kg body weight), a soft nucleophilic and
Publikováno v:
Biochimica et biophysica acta. 1587(1)
Our studies of renal phosphoinositide levels and metabolism in the pcy mouse with polycystic kidney disease (PKD) suggest that phosphatidylinositol kinase (PtdInsK) and phospholipase C (PLC) are elevated in this renal disorder. Therefore, the steady-
Publikováno v:
Biochimica et biophysica acta. 1553(3)
We compared NAD-dependent state 4 and state 3 respiration, NADH oxidation and Complex I specific activity in liver mitochondria from 4- and 30-month-old rats. All the activities examined were significantly decreased with aging. In both groups of anim
Autor:
Marie-Christine Beauvieux, Pierre Tissier, Paul Canioni, Patrice Couzigou, H. Gin, Jean-Louis Gallis
Publikováno v:
Biochimica et biophysica acta. 1570(2)
The question arises as to the effect of ethanol on the actual yield of oxidative phosphorylation in the whole liver because of contradictory results reported in isolated hepatic mitochondria. The adenosine triphosphate (ATP) content of liver isolated
Autor:
Masanori Suzuki, Keiji Miyata, Masahide Goto, Satomi Nishijima, Hirotoshi Kakuta, Hideyuki Tanaka, Shuhei Yasuda, Motoko Ida, Toshiyuki Funatsu
Publikováno v:
Biochimica et biophysica acta. 1580(2-3)
The mechanism by which atorvastatin lowers plasma triglyceride (TG) levels is mainly through a decrease in hepatic TG secretion. However, it is not clear why atorvastatin, which does not inhibit TG synthesis in vitro, decreases hepatic TG secretion w
Publikováno v:
Biochimica et biophysica acta. 1559(2)
Mammalian Mrp2 and its yeast orthologue, Ycf1p, mediate the ATP-dependent cellular export of a variety of organic anions. Ycf1p also appears to transport the endogenous tripeptide glutathione (GSH), whereas no ATP-dependent GSH transport has been det