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Autor:
Tatsuya Morimoto, Hidetoshi Suzuki, Yoichi Sunagawa, Koji Hasegawa, Masafumi Funamoto, Yasufumi Katanasaka, Yusuke Miyazaki, Hiromichi Wada
Publikováno v:
Biochimica et biophysica acta. 1862(9)
The zinc finger protein GATA4 is a transcription factor involved in cardiomyocyte hypertrophy. It forms a functional complex with the intrinsic histone acetyltransferase (HAT) p300. The HAT activity of p300 is required for the acetylation and transcr
Autor:
Nicolás Octavio Favale, Norma B. Sterin-Speziale, Bruno Jaime Santacreu, Lucila Gisele Pescio, María Gabriela Márquez
Publikováno v:
Biochimica et biophysica acta. 1861(6)
Phosphatidylcholine (PC) is the main constituent of mammalian cell membranes. Consequently, preservation of membrane PC content and composition - PC homeostasis - is crucial to maintain cellular life. PC biosynthetic pathway is generally controlled b
Autor:
Veronika Somoza, Peter Steinberger, Michael Wolzt, Daniel Doberer, Guido A. Gualdoni, Gerhard J. Zlabinger, Marc Pignitter, Franziska Dose, Johannes J. Kovarik, Johannes Hofer
Publikováno v:
Biochimica et biophysica acta. 1840(1)
Background Resveratrol is a key component of red wine that has been reported to have anti-carcinogenic and anti-aging properties. Additional studies conducted in vitro and in animal models suggested anti-inflammatory properties. However, data from pr
Autor:
Jana Mládková, Martina Chrudinová, Marek Kořínek, Zuzana Demianová, Irena Selicharová, Jiří Jiráček
Publikováno v:
Biochimica et biophysica acta. 1834(8)
Both cardiovascular disease and liver injury are major public health issues. Hyperhomocysteinemia has been linked to cardiovascular diseases, and defects in methyl group metabolism, often resulting in hyperhomocysteinemia, are among the key molecular
Autor:
Munehiro Kitada, Keizo Kanasaki, Shin-ichi Tsuda, Ai Takeda-Watanabe, Shinji Kume, Daisuke Koya
Publikováno v:
Biochimica et biophysica acta. 1830(10)
Background Calorie restriction (CR) is accepted as an experimental anti-aging paradigm. Several important signal transduction pathways including AMPK and SIRT1 are implicated in the regulation of physiological processes of CR. However, the mechanisms
Publikováno v:
Biochimica et biophysica acta. 1829(10)
In various human malignancies, widespread dysregulation of microRNA (miRNA) expression is reported to occur and affects various cell growth programs. Recent studies suggest that the expression levels of miRNAs that act as tumor suppressors are freque
Publikováno v:
Biochimica et biophysica acta. 1820(10)
Background Lead (Pb) exposure is considered as a risk factor for the development of renal dysfunction. The flavonoid quercetin (QE) in diets exerts the nephroprotective effects. This study investigated the effects of quercetin on renal oxidative stre
Autor:
Robert M. Sargis, Brian A. Neel, Yuxi Lin, Clifton O. Brock, Allison T. Hickey, Matthew J. Brady, Daniel A. Carlton
Publikováno v:
Biochimica et biophysica acta. 1822(6)
Emerging data suggest that environmental endocrine disrupting chemicals may contribute to the pathophysiology of obesity and diabetes. In a prior work, the phenylsulfamide fungicide tolylfluanid (TF) was shown to augment adipocyte differentiation, ye
Role of endothelial dysfunction in modulating the plasma redox homeostasis in visceral leishmaniasis
Publikováno v:
Biochimica et biophysica acta. 1810(7)
Background Evidence in the literature suggests that down-regulation of nitric oxide (NO) is associated with the pathophysiological conditions during visceral leishmaniasis (VL). Here we have investigated the mechanism that leads to the down regulatio
Autor:
Heike Olbrich, Anke Sommer, Ralf Seul, Jörn Oliver Sass, Heymut Omran, Ernst Christensen, Susanne Schwenger, Dorothea Haas
Publikováno v:
Biochimica et biophysica acta. 1812(6)
Aminoacylase 1 is a zinc-binding enzyme which hydrolyzes N-acetyl amino acids into the free amino acid and acetic acid. Deficiency of aminoacylase 1 due to mutations in the aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritanc