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Autor:
Katsumi Matsuzaki
Publikováno v:
Biochimica et biophysica acta. 1862(8)
It is widely accepted that the abnormal self-association of amyloid β-protein (Aβ) is central to the pathogenesis of Alzheimer's disease, the most common form of dementia. Accumulating evidence, both in vivo and in vitro, suggests that the binding
Autor:
Bhosale, Gauri, Sharpe, Jenny A., Koh, Amanda, Kouli, Antonina, Szabadkai, Gyorgy, Duchen, Michael R.
Publikováno v:
Biochimica et Biophysica Acta
Loss of function mutations of the protein MICU1, a regulator of mitochondrial Ca2 + uptake, cause a neuronal and muscular disorder characterised by impaired cognition, muscle weakness and an extrapyramidal motor disorder. We have shown previously tha
Autor:
Fumiaki Sato, Wenzhao Li, Atsuo Iida, Sunao Tanaka, Junji Itou, Masakazu Toi, Atsuko Sehara-Fujisawa
Publikováno v:
Biochimica et biophysica acta. 1864(1):76-88
During metastasis, cancer cell migration is enhanced. However, the mechanisms underlying this process remain elusive. Here, we addressed this issue by functionally analyzing the transcription factor Sal-like 4 (SALL4) in basal-like breast cancer cell
Publikováno v:
Biochimica et biophysica acta, 1863(5):17661, 902-910
This contribution describes the phenotypic differences of yeast peroxisome-deficient mutants (pex mutants). In some cases different phenotypes were reported for yeast mutants deleted in the same PEX gene. These differences are most likely related to
Autor:
Ehler, Elisabeth
Publikováno v:
Biochimica et Biophysica Acta
Ehler, E 2016, ' Cardiac cytoarchitecture : why the "hardware" is important for heart function! ', Biochimica et biophysica acta-Molecular cell research, vol. 1863, no. 7, pp. 1857-1863 . https://doi.org/10.1016/j.bbamcr.2015.11.006
Ehler, E 2016, ' Cardiac cytoarchitecture : why the "hardware" is important for heart function! ', Biochimica et biophysica acta-Molecular cell research, vol. 1863, no. 7, pp. 1857-1863 . https://doi.org/10.1016/j.bbamcr.2015.11.006
Cells that constitute fully differentiated tissues are characterised by an architecture that makes them perfectly suited for the job they have to do. This is especially obvious for cardiomyocytes, which have an extremely regular shape and display a p
Autor:
Eden, Emily R.
Publikováno v:
Biochimica et Biophysica Acta
Recent advances in membrane contact site (MCS) biology have revealed key roles for MCSs in inter-organellar exchange, the importance of which is becoming increasingly apparent. Roles for MCSs in many essential physiological processes including lipid
Autor:
Valéry Payen, Pierre Sonveaux, Jhudit Pérez-Escuredo, Luc Pellerin, Jorge Falces, Vincent F. Van Hée, Martina Sboarina
Publikováno v:
Biochimica et Biophysica Acta
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage a
Autor:
Griffiths, William J., Wang, Yuqin
Publikováno v:
Biochimica et Biophysica Acta
Sterolomics can be thought of as the quantitative determination of the entire complement of molecules based on the cyclopentanoperhydrophenanthrene skeleton in a system. Mass spectrometry is the dominant analytical technology employed. In this articl
Autor:
Thierry Claudel, Alastair J.M. Watson, Michaela Lang, Jonathan M. Williams, Vineeta Khare, Rayko Evstatiev, Felix Harpain, Nicolas Granofszky, D. Mark Pritchard, Christoph Gasche, Kyle Dammann
Publikováno v:
Biochimica et Biophysica Acta
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with both kinase and scaffolding activity. Here, we investigated the effects of inflammation on PAK1 signaling and its role in colitis-driven carcinogenesis. PAK1 and p-PAK1 (T
Publikováno v:
Biochimica et Biophysica Acta
The fluid mosaic model of Singer and Nicolson correctly predicted that the plasma membrane (PM) forms a lipid bi-layer containing many integral trans-membrane proteins. This model also suggested that most of these proteins were randomly dispersed and