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Autor:
Kazuhiro Iwai
Publikováno v:
Biochimica et biophysica acta. 1843(1):129-136
NF-κB is a transcription factor known to be involved in pleomorphic biological phenomena such as inflammation and immune responses. Abnormal activation of NF-κB has been reported in many pathological conditions, including allergic and auto-inflamma
Autor:
Charles Affourtit, Raid B. Nisr
Publikováno v:
Biochimica et Biophysica Acta
Insulin is essential for the regulation of fuel metabolism and triggers the uptake of glucose by skeletal muscle. The imported glucose is either stored or broken down, as insulin stimulates glycogenesis and ATP synthesis. The mechanism by which ATP p
Publikováno v:
Biochimica et biophysica acta. 1864(12)
The interplay of the presence of nickel and protein disorder in processes affecting human health is the focus of the present review. Many systems involving nickel as either a cofactor or as a toxic contaminant are characterized by large disorder. The
Publikováno v:
Biochimica et Biophysica Acta
HIPK2 (homeodomain-interacting protein kinase-2) binds to and phosphorylates, at Ser and Thr residues, a large number of targets involved in cell division and cell fate decision in response to different physiological or stress stimuli. Inactivation o
Publikováno v:
Biochimica et Biophysica Acta
Intermediate filaments are cytoskeletal elements important for cell architecture. Recently it has been discovered that intermediate filaments are highly dynamic and that they are fundamental for organelle positioning, transport and function thus bein
Publikováno v:
Biochimica et Biophysica Acta
Mutations in the gene encoding strumpellin cause autosomal dominant hereditary spastic paraplegia (HSP), in which there is degeneration of corticospinal tract axons. Strumpellin is a component of the WASH complex, an actin-regulating complex that is
Autor:
Kaya, Levent, Meissner, Barbara, Riedl, Maria Christine, Muik, Martin, Schwarzer, Christoph, Ferraguti, Francesco, Sarg, Bettina, Lindner, Herbert, Schweigreiter, Rüdiger, Knaus, Hans-Günther, Romanin, Christoph, Bandtlow, Christine E.
Publikováno v:
Biochimica et Biophysica Acta
RTN1A is a reticulon protein with predominant localization in the endoplasmic reticulum (ER). It was previously shown that RTN1A is expressed in neurons of the mammalian central nervous system but functional information remains sparse. To elucidate t
Publikováno v:
Biochimica et biophysica acta. 1858(12)
Haloacids are considered to be environmental pollutants, but some of them have also been tested in clinical research. The way that haloacids are transported across biological membranes is important for both biodegradation and drug delivery purposes.
Publikováno v:
Biochimica et biophysica acta. 1861(12 Pt)
Autor:
Hans-Ulrich Häring, Xinjie Zhao, Till Adhikary, Guowang Xu, Rainer Lehmann, Cora Weigert, Erwin Schleicher, Christian Klingler, Jia Li
Publikováno v:
Biochimica et biophysica acta. 1861(12 Pt)
Metabolomics studies of human plasma demonstrate a correlation of lower plasma lysophosphatidylcholines (LPC) concentrations with insulin resistance, obesity, and inflammation. This relationship is not unraveled on a molecular level. Here we investig