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Autor:
Fumiaki Sato, Wenzhao Li, Atsuo Iida, Sunao Tanaka, Junji Itou, Masakazu Toi, Atsuko Sehara-Fujisawa
Publikováno v:
Biochimica et biophysica acta. 1864(1):76-88
During metastasis, cancer cell migration is enhanced. However, the mechanisms underlying this process remain elusive. Here, we addressed this issue by functionally analyzing the transcription factor Sal-like 4 (SALL4) in basal-like breast cancer cell
Publikováno v:
Biochimica et biophysica acta, 1863(5):17661, 902-910
This contribution describes the phenotypic differences of yeast peroxisome-deficient mutants (pex mutants). In some cases different phenotypes were reported for yeast mutants deleted in the same PEX gene. These differences are most likely related to
Autor:
Thierry Claudel, Alastair J.M. Watson, Michaela Lang, Jonathan M. Williams, Vineeta Khare, Rayko Evstatiev, Felix Harpain, Nicolas Granofszky, D. Mark Pritchard, Christoph Gasche, Kyle Dammann
Publikováno v:
Biochimica et Biophysica Acta
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with both kinase and scaffolding activity. Here, we investigated the effects of inflammation on PAK1 signaling and its role in colitis-driven carcinogenesis. PAK1 and p-PAK1 (T
Autor:
Kazuhiro Iwai
Publikováno v:
Biochimica et biophysica acta. 1843(1):129-136
NF-κB is a transcription factor known to be involved in pleomorphic biological phenomena such as inflammation and immune responses. Abnormal activation of NF-κB has been reported in many pathological conditions, including allergic and auto-inflamma
Publikováno v:
Biochimica et biophysica acta. 1864(12)
The interplay of the presence of nickel and protein disorder in processes affecting human health is the focus of the present review. Many systems involving nickel as either a cofactor or as a toxic contaminant are characterized by large disorder. The
Publikováno v:
Biochimica et biophysica acta. 1861(11)
Stearoyl-CoA desaturase (SCD), the central enzyme in the biosynthesis of monounsaturated fatty acids, introduces a cis-Δ9 double bond into saturated fatty acids. SCD-1 has been proposed as promising target for the treatment of cancer, skin disorders
Autor:
Takashi Hoshiba, Masaru Tanaka
Publikováno v:
Biochimica et biophysica acta. 1863(11)
Chemoresistance is a major barrier for tumor chemotherapy. It is well-known that chemoresistance increases with tumor progression. Chemoresistance is altered by both genetic mutations and the alteration of extracellular microenvironment. Particularly
Publikováno v:
Biochimica et biophysica acta. 1863(12)
Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor that monitors ATP levels. There is also evidence that AMPK has onco-suppressive properties. Iron plays a crucial role in cellular energy transducing pathways and tumo
Publikováno v:
Biochimica et biophysica acta. 1863(12)
PTEN is a tumor suppressor gene characterized as a phosphatase that antagonizes the phosphatidylinositol 3-kinase signaling pathway in the cytoplasm. Nuclear PTEN plays roles in chromosomal stability, in which the double-strand breaks (DSB) repair me
Publikováno v:
Biochimica et biophysica acta. 1862(10)
Protein phosphorylation of serine, threonine, and tyrosine residues is one of the most prevalent post-translational modifications fundamental in mediating diverse cellular functions in living cells. Aberrant protein phosphorylation is currently recog