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Publikováno v:
Biochimica et biophysica acta. 1861(11)
Stearoyl-CoA desaturase (SCD), the central enzyme in the biosynthesis of monounsaturated fatty acids, introduces a cis-Δ9 double bond into saturated fatty acids. SCD-1 has been proposed as promising target for the treatment of cancer, skin disorders
Autor:
Bernhard Brüne, Dmitry Namgaladze
Publikováno v:
Biochimica et biophysica acta. 1861(11)
Recent research considerably changed our knowledge how cellular metabolism affects the immune system. We appreciate that metabolism not only provides energy to immune cells, but also actively influences diverse immune cell phenotypes. Fatty acid meta
Publikováno v:
Biochimica et biophysica acta. 1858(11)
Plasma membrane disruption can trigger a host of cellular activities. One commonly observed type of disruption is pore formation. Molecular dynamic (MD) simulations of simplified lipid membrane structures predict that controllably disrupting the memb
Publikováno v:
Biochimica et biophysica acta. 1862(9)
Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with various biological phenomena. However, the role of glycolysis induced by arsenite, a well-established human carcinogen, is unknown. Long non-coding
Autor:
Guenter Haemmerle, Christoph Heier
Publikováno v:
Biochimica et biophysica acta. 1861(10)
The heart predominantly utilizes fatty acids (FAs) as energy substrate. FAs that enter cardiomyocytes can be activated and directly oxidized within mitochondria (and peroxisomes) or they can be esterified and intracellularly deposited as triacylglyce
Publikováno v:
Biochimica et biophysica acta. 1863(9)
Steroid hormones regulate a wide variety of physiological and developmental functions. Traditional steroid hormone signaling acts through nuclear and cytosolic receptors, altering gene transcription and subsequently regulating cellular activity. This
Publikováno v:
Biochimica et biophysica acta. 1862(9)
Choroidal neovascularization (CNV) is a major cause of vision loss in many retinal diseases. Hypoxia is determined to be a key inducer of CNV and hypoxia-inducible factor-1 (HIF-1) is an important transcription factor. Epithelial-mesenchymal transiti
Autor:
Victor V. Lemeshko
Publikováno v:
Biochimica et biophysica acta. 1858(7 Pt)
Mitochondrial energy in cardiac cells has been reported to be channeled into the cytosol through the intermembrane contact sites formed by the adenine nucleotide translocator, creatine kinase and VDAC. Computational analysis performed in this study s
Publikováno v:
Biochimica et biophysica acta. 1858(8)
The clathrin-mediated endocytosis is likely a major mechanism of liposomes' internalization. A kinetic approach was used to assess the internalization mechanism of doxorubicin (Dox) loaded cationic liposomes and to establish physiology-based cell mem
Autor:
Norman J. Maitland, John R. Packer
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling epidemiology, there are no definitive aetiological clues linking development to frequency. Pre-malignancies such as proliferative inflammatory atrophy (PIA) and prosta