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Autor:
Roland Lill, Viktoria Désirée Paul
Publikováno v:
Biochimica et biophysica acta. 1853(6)
Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of cytosolic and nuclear Fe–S proteins is accomplished by cooperation of
Publikováno v:
Biochimica et biophysica acta. 1837(4)
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a characteristic “network structure” that facilitates the formation of interorganellar connections. The ER and mitochondria join together at multiple contact sites to for
Publikováno v:
Biochimica et Biophysica Acta, 1837(4), 418-426
Oxidative phosphorylation (OXPHOS) is the main source of energy in eukaryotic cells. This process is performed by means of electron flow between four enzymes, of which three are proton pumps, in the inner mitochondrial membrane. The energy accumulate
Publikováno v:
Biochim Biophys Acta
Mitochondrial proteostasis depends on a hierarchical system of tightly controlled quality surveillance mechanisms. Proteases within mitochondria take center stage in this network. They eliminate misfolded and damaged proteins and ensure the biogenesi
Publikováno v:
Biochimica et biophysica acta. 1807(6)
The histidine triad (HIT) superfamily comprises proteins that share the histidine triad motif, His-ϕ-His-ϕ-His-ϕ–ϕ, where ϕ is a hydrophobic amino acid. HIT proteins are ubiquitous in prokaryotes and eukaryotes. HIT proteins bind nucleotides a
Autor:
Imke M. Willers, José M. Cuezva
Publikováno v:
Biochimica et biophysica acta. 1807(6)
A distinctive metabolic trait of tumors is their enforced aerobic glycolysis. This phenotype was first reported by Otto Warburg, who suggested that the increased glucose consumption of cancer cells under aerobic conditions might result from an impair
Publikováno v:
Biochimica et Biophysica Acta. B, Bioenergetics 1807 (2011) 6
Biochimica et Biophysica Acta. B, Bioenergetics, 1807(6), 697-706
Biochimica et Biophysica Acta. B, Bioenergetics, 1807(6), 697-706
Cancer cells are resistant to apoptosis and show a shift in energy production from mitochondrial oxidative phosphorylation to cytosolic glycolysis. Apoptosis resistance and metabolic reprogramming are linked in many cancer cells and both processes ce
Autor:
Anne-Laure Bulteau, Aurélien Bayot
Publikováno v:
Biochimica et biophysica acta. 1807(6)
Mitochondria are a major source of intracellular reactive oxygen species, the production of which increases with cancer. The deleterious effects of reactive oxygen species may be responsible for the impairment of mitochondrial function observed durin
Publikováno v:
Biochimica et biophysica acta. 1807(6)
During the last decades a considerable amount of research has been focused on cancer. Recently, tumor cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display enhanced glycolytic activity
Publikováno v:
Biochimica et biophysica acta. 1807(6)
Evidence suggests that mitochondrial metabolism may play a key role in controlling cancer cells life and proliferation. Recent evidence also indicates how the altered contribution of these organelles to metabolism and the resistance of cancer mitocho