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Publikováno v:
Biochimica et biophysica acta. 1864(12)
The interplay of the presence of nickel and protein disorder in processes affecting human health is the focus of the present review. Many systems involving nickel as either a cofactor or as a toxic contaminant are characterized by large disorder. The
Autor:
Dimitri Fishman, Michal Hersfinkel, Yaki Caspi, Shaya Lev, Alexander M. Binshtok, Iulia I. Nita, Israel Sekler, Sagi Gudes
Publikováno v:
Biochimica et biophysica acta. 1863(12)
The nociceptive noxious heat-activated receptor - TRPV1, conducts calcium and sodium, thus producing a depolarizing receptor potential, leading to activation of nociceptive neurons. TRPV1-mediated calcium and sodium influx is negatively modulated by
Publikováno v:
Biochimica et biophysica acta. 1858(11)
Previous work from our laboratory demonstrated nanopore formation in cell membranes following exposure to nanosecond pulsed electric fields (nsPEF). We observed differences in sensitivity to nsPEF in both acute membrane injury and 24 h lethality acro
Autor:
Joshua Brownlee, Charles W. Putnam, Jesse D. Martinez, Jamie Borg, Sara M. Centuori, Jesse Trujillo, Cecil J. Gomes
Publikováno v:
Biochimica et biophysica acta. 1861(7)
Obesity and a western diet have been linked to high levels of bile acids and the development of colon cancer. Specifically, increased levels of the bile acid deoxycholic acid (DCA), an established tumor promoter, has been shown to correlate with incr
Autor:
Hugues Abriel, Jean-Sébastien Rougier
Publikováno v:
Biochimica et biophysica acta. 1863(7 Pt)
Over the past 20 years, a new field of research, called channelopathies, investigating diseases caused by ion channel dysfunction has emerged. Cardiac ion channels play an essential role in the generation of the cardiac action potential. Investigator
Autor:
Shunichi Fukuzumi
Publikováno v:
Biochimica et biophysica acta. 1857(5)
The reducing power released from photosystem I (PSI) via ferredoxin enables the reduction of NADP(+) to NADPH, which is essential in the Calvin-Benson cycle to make sugars in photosynthesis. Alternatively, PSI can reduce O2 to produce hydrogen peroxi
Autor:
Randal J. Kaufman, Jyoti D. Malhotra
Publikováno v:
Biochimica et biophysica acta. 1843(10)
Calcium homeostasis is central to all cellular functions and has been studied for decades. Calcium acts as a critical second messenger for both extracellular and intracellular signaling and is fundamental in cell life and death decisions (Berridge et
Autor:
Wesley H. Brooks, Sreya Mukherjee
Publikováno v:
Biochimica et biophysica acta. 1843(10)
Calcium ions have important roles in cellular processes including intracellular signaling, protein folding, enzyme activation and initiation of programmed cell death. Cells maintain low levels of calcium in their cytosol in order to regulate these pr
Autor:
Paula Martínez-Valero, Beatriz Pardo, Laura Contreras, Jorgina Satrústegui, Paloma González-Sánchez, Ignacio Amigo, Inés Juaristi, Irene Llorente-Folch, Carlos B. Rueda, Araceli del Arco
Publikováno v:
Biochimica et biophysica acta. 1837(10)
Calcium is thought to regulate respiration but it is unclear whether this is dependent on the increase in ATP demand caused by any Ca(2+) signal or to Ca(2+) itself. [Na(+)]i, [Ca(2+)]i and [ATP]i dynamics in intact neurons exposed to different workl
Publikováno v:
Biochimica et biophysica acta. 1838(3)
Calcium has been shown to induce clustering of PI(4,5)P2 at high and non-physiological concentrations of both the divalent ion and the phosphatidylinositol, or on supported lipid monolayers. In lipid bilayers at physiological conditions, clusters are