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Autor:
Bhosale, Gauri, Sharpe, Jenny A., Koh, Amanda, Kouli, Antonina, Szabadkai, Gyorgy, Duchen, Michael R.
Publikováno v:
Biochimica et Biophysica Acta
Loss of function mutations of the protein MICU1, a regulator of mitochondrial Ca2 + uptake, cause a neuronal and muscular disorder characterised by impaired cognition, muscle weakness and an extrapyramidal motor disorder. We have shown previously tha
Autor:
Kaya, Levent, Meissner, Barbara, Riedl, Maria Christine, Muik, Martin, Schwarzer, Christoph, Ferraguti, Francesco, Sarg, Bettina, Lindner, Herbert, Schweigreiter, Rüdiger, Knaus, Hans-Günther, Romanin, Christoph, Bandtlow, Christine E.
Publikováno v:
Biochimica et Biophysica Acta
RTN1A is a reticulon protein with predominant localization in the endoplasmic reticulum (ER). It was previously shown that RTN1A is expressed in neurons of the mammalian central nervous system but functional information remains sparse. To elucidate t
Autor:
Dimitri Fishman, Michal Hersfinkel, Yaki Caspi, Shaya Lev, Alexander M. Binshtok, Iulia I. Nita, Israel Sekler, Sagi Gudes
Publikováno v:
Biochimica et biophysica acta. 1863(12)
The nociceptive noxious heat-activated receptor - TRPV1, conducts calcium and sodium, thus producing a depolarizing receptor potential, leading to activation of nociceptive neurons. TRPV1-mediated calcium and sodium influx is negatively modulated by
Publikováno v:
Biochimica et biophysica acta. 1858(11)
Previous work from our laboratory demonstrated nanopore formation in cell membranes following exposure to nanosecond pulsed electric fields (nsPEF). We observed differences in sensitivity to nsPEF in both acute membrane injury and 24 h lethality acro
Autor:
Victor V. Lemeshko
Publikováno v:
Biochimica et biophysica acta. 1858(7 Pt)
Mitochondrial energy in cardiac cells has been reported to be channeled into the cytosol through the intermembrane contact sites formed by the adenine nucleotide translocator, creatine kinase and VDAC. Computational analysis performed in this study s
Autor:
Joshua Brownlee, Charles W. Putnam, Jesse D. Martinez, Jamie Borg, Sara M. Centuori, Jesse Trujillo, Cecil J. Gomes
Publikováno v:
Biochimica et biophysica acta. 1861(7)
Obesity and a western diet have been linked to high levels of bile acids and the development of colon cancer. Specifically, increased levels of the bile acid deoxycholic acid (DCA), an established tumor promoter, has been shown to correlate with incr
Autor:
Nicolas Tajeddine
Publikováno v:
Biochimica et biophysica acta. 1860(6)
Background Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injurie
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
Intracellular Ca(2+) signals that arise from the endoplasmic reticulum (ER), the major intracellular Ca(2+)-storage organelle, impact several mitochondrial functions and dictate cell survival and cell death processes. Furthermore, alterations in Ca(2
Autor:
Huamei Forsman, Tudor I. Oprea, André Holdfeldt, Michael Gabl, Claes Dahlgren, Johan Bylund, Malene Winther
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
Several G-protein-coupled receptors (GPCRs) can be activated or inhibited in a specific manner by membrane-permeable pepducins, which are short palmitoylated peptides with amino acid sequences identical to an intracellular domain of the receptor to b
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is ubiquitously expressed, implying a wide range of functions regulated by thi