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Publikováno v:
Biochimica et biophysica acta. 1860(11 Pt)
Methods 8-week-age male ApoE−/− mice were fed with the atherogenic diet together with or without tested compounds (rosuvastatin calcium, α-LNA-LMWCS, LMWCS and α-LNA) for 16 weeks. When the animals were killed, blood plasma was isolated to test
Publikováno v:
Biochimica et biophysica acta. 1860(8)
Background Understanding of the significance of posttranslational glycosylation in Alzheimer's disease (AD) is of growing importance for the investigation of the pathogenesis of AD as well as discovery research of the disease-specific serum biomarker
Autor:
Devis Galesso, Susanna Vaccaro, Mauro Pavan, Susi Panfilo, Riccardo Beninatto, Cristian Guarise, Luciano Messina
Publikováno v:
Biochimica et biophysica acta. 1860(4)
Background Recombinant human hyaluronidase has been used in the interstitial matrix to promote the dispersion of therapeutics. The production and isolation of an extracellular hyaluronidase from Streptomyces koganeiensis (rHyal_Sk) has recently been
Autor:
Kenneth B. Storey, Neal J. Dawson
Publikováno v:
Biochimica et biophysica acta. 1860(3)
Background The North American wood frog, Rana sylvatica , endures whole body freezing while wintering on land and has developed multiple biochemical adaptations to elude cell/tissue damage and optimize its freeze tolerance. Blood flow is halted in th
Autor:
Xavier Bellés, Ana Fernandez-Nicolas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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[Background] CREB-binding protein (CBP) is a promiscuous transcriptional co-regulator. In insects, CBP has been studied in the fly Drosophila melanogaster, where it is known as Nejire. Studies in D. melanogaster have revealed that Nejire is involved
Autor:
Tadigoppula Narender, Gopalapura J. Vishalakshi, R.M. Thushara, Rachana D. Sharma, Kesturu S. Girish, Kempaiah Kemparaju, G. Madhur, Somanathapura K. NaveenKumar, Gajanan D. Katkar
Publikováno v:
Biochimica et biophysica acta. 1850(12)
Background Echis carinatus bite is a serious threat in South-Asian countries including India, as it causes highest number of deaths and terrifying long-term tissue destruction at the bitten site. Although venom metalloproteinases and hyaluronidases a
Autor:
María Eugenia Sarasquete, Norma C. Gutiérrez, Rocío Corral, Luis A. Corchete, Ana A. Martín, Ramón García-Sanz, Irena Misiewicz-Krzeminska, Jesús F. San Miguel, Patryk Krzemiński
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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[Context]: MiR-155 plays a critical role in the development of B-cell malignancies. Previous studies have shown a deregulation of miR-155 in specific cytogenetic subtypes of multiple myeloma (MM). However, the mechanisms that regulate miR-155 express
Publikováno v:
Biochimica et biophysica acta. 1850(7)
Background BMI and ADAMTS13 levels are positively correlated in man. Development of obesity is associated with angiogenesis and inflammation, and increased ADAMTS13 synthesis in the liver. Methods Male wild-type (WT) and ADAMTS13 deficient ( Adamts13
Autor:
Hiroshi Hinou, Shin-Ichiro Nishimura, Solomon T. Gizaw, Tetsu Ohashi, Toshiaki Koda, Keiko Kamimura, Maho Amano
Publikováno v:
Biochimica et biophysica acta. 1850(9)
Background Huntington's disease (HD) is an autosomal, dominantly inherited and progressive neurodegenerative disease, nosologically classified as the presence of intranuclear inclusion bodies and the loss of GABA-containing neurons in the neostriatum
Publikováno v:
Biochimica et biophysica acta. 1850(4)
Background Andrographolide (Andro) is reported to inhibit hepatoma tumor growth in our previous studies. This study aims to further search the critical signals involved in such Andro-induced inhibition. Methods The anti-tumor effect of Andro was eval