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Publikováno v:
Biochimica et biophysica acta. 1820(11)
Background De novo fatty acid synthesis catalyzed by fatty acid synthase (FASN) is crucial for tumor cell survival. Thus therapeutic targeting of FASN is considered as a novel antineoplastic strategy. However, little is understood in this respect reg
Publikováno v:
Biochimica et biophysica acta. 1820(10)
Background Lead (Pb) exposure is considered as a risk factor for the development of renal dysfunction. The flavonoid quercetin (QE) in diets exerts the nephroprotective effects. This study investigated the effects of quercetin on renal oxidative stre
Autor:
Ana Luiza Nascimento, Juliana K.B. Soares, Ana Paula Rocha-de-Melo, Rubem Carlos Araújo Guedes, Marco Aurélio Delmondes Bomfim, Maria do Carmo Medeiros, Rita de Cássia Ramos do Egypto Queiroga, Amanda Fernandes Oliveira de Souza
Publikováno v:
Biochimica et biophysica acta. 1820(10)
BackgroundConjugated linoleic acids (CLA) are fatty acids that are found in the lipids from goat milk, and appear to protect neurons from excitotoxicity.MethodsWe investigated in developing rats the effects of a maternal CLA-rich diet (containing 7%
Autor:
Nadezda Apostolova, Antonio Hernández-Mijares, Remedios Garcia-Bou, Victor M. Victor, Raul Herance, Milagros Rocha
Publikováno v:
BBA-BIOENERGETICS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
The medical use of nitroglycerin (GTN) is limited by patient tolerance. The present study evaluated the role of mitochondrial Complex I in GIN biotransformation and the therapeutic effect of mitochondrial antioxidants. The development of GIN toleranc
Publikováno v:
Biochimica et biophysica acta. 1818(5)
In one of the most extensive analyses to date we show that the balance of diet n−3 and n−6 polyunsaturated fatty acids (PUFA) is the most important determinant of membrane composition in the rat under ‘normal’ conditions. Young adult male Spr
Publikováno v:
Biochimica et biophysica acta. 1820(2)
Background The aim of this work was to evaluate the hepatoprotective ability of allopurinol to prevent the liver injury induced by carbon tetrachloride (CCl 4 ). Methods Acute liver damage was induced with CCl 4 (4 g/kg, by gavage); allopurinol (50 m
Publikováno v:
Biochimica et biophysica acta. 1810(12)
Background Activation of adenylyl cyclase (AC) by prolonged exposure of mammalian organism to morphine was demonstrated in previous studies of mechanism of action of this drug. However, expression level of individual AC isoforms was not analyzed in c
Publikováno v:
Biochimica et biophysica acta. 1820(10)
Background Neurotransmitter levels are best measured in the cerebrospinal fluid (CSF), but that requires an invasive procedure. Methods Samples were collected from humans and rats. Eighteen women age 38–51 years with fibromyalgia provided samples o
Publikováno v:
Biochimica et biophysica acta. 1820(5)
Background Mitochondrial dysfunction is a prominent feature of neurodegenerative diseases including Parkinson's disease (PD), in which insulin signaling pathway may also be implicated because 50–80% of PD patients exhibited metabolic syndrome and i
Autor:
Jessica Ka-Yan Law, Sven Ingebrandt, Chi-Kong Yeung, John A. Rudd, Mansun Chan, Song Wan, H. Y. A. Lau
Publikováno v:
Biochimica et biophysica acta. 1810(9)
Background The microelectrode array (MEA) was used to investigate the pharmacological relevance of chloride (Cl−) ions in antigen-dependent mast cell activation and the inhibitory effect of disodium cromoglycate (DSCG) on mast cell activation. Meth