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Autor:
Fiona M. La, Michael C. Phillips, Angel X. Xiao, Duyen Quach, Chongren Tang, Daniel J. Rader, Cecilia Vitali, Nicholas N. Lyssenko, John S. Millar
Publikováno v:
Biochimica et biophysica acta. 1861(12 Pt)
ATP-binding cassette transporter A1 (ABCA1) mediates formation of disc-shaped high-density lipoprotein (HDL) from cell lipid and lipid-free apolipoprotein A-I (apo A-I). Discoidal HDL particles are heterogeneous in physicochemical characteristics for
Publikováno v:
Biochimica et biophysica acta. 1860(11 Pt)
Background Autophagy is a critical process in acquiring drug resistance in solid tumors. However, the mechanisms by which autophagy modulate resistance to chemotherapy in bladder cancer remains poorly understood. Material and methods We have establis
Autor:
Russel J. Reiter, Jerry Vriend
Publikováno v:
Biochimica et biophysica acta. 1865(2)
There are numerous reports that melatonin inhibits the hypoxia-inducible factor, HIF-1α, and the HIF-1α-inducible gene, VEGF, both in vivo and in vitro. Through the inhibition of the HIF-1-VEGF pathway, melatonin reduces hypoxia-induced angiogenesi
Autor:
Changill Ban, Ji Young Kim, Youngkwan Cho, Hunho Jo, Jae Hong Seo, Nahyun Lee, Hyunsook An, Eunhye Oh
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
The angiotensin II type I receptor (AGTR1) has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression. We sought to investigate the role of AGTR1 in cell prolife
Autor:
Lais Alonso, Antonio Alonso
Publikováno v:
Biochimica et biophysica acta. 1858(6)
Miltefosine possesses antiparasitic, antibacterial, antifungal and antitumor activities; however, its mechanism of action is not well established. In the current work, the miltefosine concentrations required to achieve 50% hemolysis in PBS were shown
Publikováno v:
Biochimica et biophysica acta. 1863(7 Pt)
Starting from the late embryonic development, the sympathetic nervous system extensively innervates the heart and modulates its activity during the entire lifespan. The distribution of myocardial sympathetic processes is finely regulated by the secre
Publikováno v:
Biochimica et biophysica acta. 1863(7 Pt)
Anthracyclines, such as doxorubicin, are the most potent and widely used chemotherapeutic agents for the treatment of a variety of human cancers, including solid tumors and hematological malignancies. However, their clinical use is hampered by severe
Autor:
Mario Bonomini, Arduino Arduini, Mariafrancesca Scalise, Sara Di Silvestre, Stefania Belviso, Lorena Pochini, Cesare Indiveri, Assunta Pandolfi
Publikováno v:
Biochimica et biophysica acta. 1858(4)
A suitable experimental tool based on proteoliposomes for assaying Organic Cation Transporter Novel member 1 (OCTN1) of peritoneum was pointed out. OCTN1, recently acknowledged as acetylcholine transporter, was immunodetected in rat peritoneum. Trans
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
β-Amyloid (Aβ), a hallmark peptide of Alzheimer's disease, induces both caspase-dependent apoptosis and non-apoptotic cell death. In this study, we examined caspase-independent non-apoptotic cell death preceding caspase activation in Aβ42-treated
Autor:
Amelia Barilli, Rossana Visigalli, Paola Puccini, Valeria Dall'Asta, Benedetta Riccardi, Filippo Ingoglia, Bianca Maria Rotoli
Publikováno v:
Biochimica et biophysica acta. 1858(2)
Carnitine plays a physiologically important role in the β-oxidation of fatty acids, facilitating the transport of long-chain fatty acids across the inner mitochondrial membrane. Distribution of carnitine within the body tissues is mainly performed b