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Publikováno v:
Biochimica et biophysica acta. 1859(8)
Background RBM39 is a serine/arginine-rich RNA-binding protein that is highly homologous to the splicing factor U2AF65. However, the role of RBM39 in alternative splicing is poorly understood. Methods In this study, RBM39-mediated global alternative
Autor:
N. Jon Shah, Daniel Frenzel, Antje Willuweit, Karl-Josef Langen, Elena Schartmann, Thomas van Groen, Dieter Willbold, Nan Jiang, Inga Kadish
Publikováno v:
Biochimica et biophysica acta. 1858(11)
The application of small peptides targeting amyloid beta (Aβ) is one of many drug development strategies for the treatment of Alzheimer's disease (AD). We have previously identified several peptides consisting solely of D-enantiomeric amino acid res
Autor:
Sotiria Tavoulari, Edmund R.S. Kunji, Roger Springett, Valerie L. Ashton, Paul G. Crichton, Martin S. King, Homa Majd, Mikhail Kibalchenko, Elizabeth Cerson, Antoniya A. Aleksandrova, Jonathan J. Ruprecht
Publikováno v:
Biochimica et biophysica acta. 1863(10)
The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the mitochondrial matrix, which are key transport steps for oxidative phosphorylation in eukaryotic organisms. The transport protein belongs to the mitochondrial carr
Autor:
Sandeep Dukare, Karl-Heinz Klempnauer
Publikováno v:
Biochimica et biophysica acta. 1859(7)
The transcription factor c-Myb plays a key role in the control of proliferation and differentiation in hematopoietic progenitor cells and has been implicated in the development of leukemia and certain non-hematopoietic tumors. c-Myb activity is highl
Autor:
Tim P. Levine, Sarah E. Murphy
Publikováno v:
Biochimica et biophysica acta. 1861(8 Pt)
Dysfunction of VAMP-associated protein (VAP) is associated with neurodegeneration, both Amyotrophic Lateral Sclerosis and Parkinson's disease. Here we summarize what is known about the intracellular interactions of VAP in humans and model organisms.
Autor:
Yongfeng He, Young-Chang Cho, Tingting Yuan, Taeyong Ryu, Moon-Chang Baek, Nensi Shrestha, Sayeon Cho, Kwonseop Kim, Hridaya Shrestha, So-Yeon Park, Shishli Simkhada, Pyong-Gon Moon, Hangun Kim, Chan-Hyeong Lee
Publikováno v:
Biochimica et biophysica acta. 1863(9)
Ubiquitination, a post-translational modification, involves the covalent attachment of ubiquitin to the target protein. The ubiquitin-proteasome pathway and the endosome-lysosome pathway control the degradation of the majority of eukaryotic proteins.
Autor:
Huamei Forsman, Tudor I. Oprea, André Holdfeldt, Michael Gabl, Claes Dahlgren, Johan Bylund, Malene Winther
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
Several G-protein-coupled receptors (GPCRs) can be activated or inhibited in a specific manner by membrane-permeable pepducins, which are short palmitoylated peptides with amino acid sequences identical to an intracellular domain of the receptor to b
Autor:
José Basílio, Muhammad Ilyas, Bernhard Hochreiter, Kalsoom Sughra, Johannes A. Schmid, Naila Malkani, Bastian Hoesel
Publikováno v:
Biochimica et biophysica acta
The transcription factor ERG is known to have divergent roles. On one hand, it acts as differentiation factor of endothelial cells. On the other hand, it has pathological roles in various cancers. Genomic analyses of the ERG gene show that it gives r
Publikováno v:
Biochimica et biophysica acta. 1861(1)
The zebrafish (Danio rerio) is frequently employed as model organism to explore vertebrate embryogenesis but little is known about the lipoxygenase pathway in this lower vertebrate. When we searched the zebrafish genome for lipoxygenase genes we dete
Autor:
Jörg O. Schulze, Ricardo M. Biondi, Antonio Casamayor, Evelyn Süß, Daniel Pastor-Flores, Anna Bahí
Publikováno v:
Biochimica et biophysica acta. 1861(3)
Pkh is the yeast ortholog of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Pkh phosphorylates the activation loop of Ypks, Tpks, Sch9 and also phosphorylates the eisosome components Lsp1 and Pil1, which play fundamental roles up