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Autor:
N. Jon Shah, Daniel Frenzel, Antje Willuweit, Karl-Josef Langen, Elena Schartmann, Thomas van Groen, Dieter Willbold, Nan Jiang, Inga Kadish
Publikováno v:
Biochimica et biophysica acta. 1858(11)
The application of small peptides targeting amyloid beta (Aβ) is one of many drug development strategies for the treatment of Alzheimer's disease (AD). We have previously identified several peptides consisting solely of D-enantiomeric amino acid res
Autor:
Sotiria Tavoulari, Edmund R.S. Kunji, Roger Springett, Valerie L. Ashton, Paul G. Crichton, Martin S. King, Homa Majd, Mikhail Kibalchenko, Elizabeth Cerson, Antoniya A. Aleksandrova, Jonathan J. Ruprecht
Publikováno v:
Biochimica et biophysica acta. 1863(10)
The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the mitochondrial matrix, which are key transport steps for oxidative phosphorylation in eukaryotic organisms. The transport protein belongs to the mitochondrial carr
Autor:
Yongfeng He, Young-Chang Cho, Tingting Yuan, Taeyong Ryu, Moon-Chang Baek, Nensi Shrestha, Sayeon Cho, Kwonseop Kim, Hridaya Shrestha, So-Yeon Park, Shishli Simkhada, Pyong-Gon Moon, Hangun Kim, Chan-Hyeong Lee
Publikováno v:
Biochimica et biophysica acta. 1863(9)
Ubiquitination, a post-translational modification, involves the covalent attachment of ubiquitin to the target protein. The ubiquitin-proteasome pathway and the endosome-lysosome pathway control the degradation of the majority of eukaryotic proteins.
Autor:
Huamei Forsman, Tudor I. Oprea, André Holdfeldt, Michael Gabl, Claes Dahlgren, Johan Bylund, Malene Winther
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
Several G-protein-coupled receptors (GPCRs) can be activated or inhibited in a specific manner by membrane-permeable pepducins, which are short palmitoylated peptides with amino acid sequences identical to an intracellular domain of the receptor to b
Autor:
Craig T. Armstrong, Joseph L. Beesley, J L R Anderson, Stephen Mann, Jane E Marsh, Jonathan M. X. Jenkins, Daniel W. Watkins, Richard B. Sessions
Publikováno v:
Watkins, D W, Armstrong, C T, Beesley, J, Marsh, J E, Jenkins, J M, Sessions, R B, Mann, S & Anderson, J L R 2016, ' A suite of de novo c-type cytochromes for functional oxidoreductase engineering ', Biochimica et Biophysica Acta (BBA)-Bioenergetics, vol. 1857, no. 5, pp. 493-502 . https://doi.org/10.1016/j.bbabio.2015.11.003
Central to the design of an efficient de novo enzyme is a robust yet mutable protein scaffold. The maquette approach to protein design offers precisely this, employing simple four-α-helix bundle scaffolds devoid of evolutionary complexity and with p
Publikováno v:
Biochimica et biophysica acta. 1857(5)
Maquettes are man-made cofactor-binding oxidoreductases designed from first principles with minimal reference to natural protein sequences. Here we focus on water-soluble maquettes designed and engineered to perform diffusive electron transport of th
Autor:
Nunziata Maio, Tracey A. Rouault
Publikováno v:
Biochimica et biophysica acta. 1853(6)
Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with many variations of cluster composition, oxidation states and protein
Publikováno v:
Biochimica et biophysica acta. 1839(11)
The cytoplasmic poly(A) binding protein 1 (PABPC1) is an essential eukaryotic translational initiation factor first described over 40 years ago. Most studies of PABPC1 have focused on its N-terminal RRM domains, which bind the mRNA 3' poly(A) tail an
Autor:
Virginie Fievez, Andy Chevigné, Martyna Szpakowska, Aurélie Fischer, Jean-Marc Plesséria, Sabrina Deroo, Jean-Claude Schmit, Manuel Counson
Publikováno v:
Biochimica et biophysica acta. 1843(5)
The chemokine receptor CXCR4 interacts with a single endogenous chemokine, CXCL12, and regulates a wide variety of physiological and pathological processes including inflammation and metastasis development. CXCR4 also binds the HIV-1 envelope glycopr
Autor:
Rawan Eid, Michael T. Greenwood, Jason F. Lapointe, Natalie K. Jones, Avital Horowitz, Hojatollah Vali, Nada Gharib, Craig A. Mandato, Sara Sheibani
Publikováno v:
Biochimica et biophysica acta. 1833(12)
The mechanisms of programmed cell death activate genetically encoded intracellular programs in a controlled manner, the most common form being apoptosis. Apoptosis is carried out through a cascade of caspase mediated proteolytic cleavages initiated b