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Autor:
Guzel S. Shurshalova, Vladimir V. Klochkov, Daniel Huster, Holger A. Scheidt, Albert V. Aganov, Markus Fischer
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101143-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Pitavastatin is a statin drug that, by competitively inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase, can lower serum cholesterol levels of low-density lipoprotein (LDL) accompanied by side effects due to pleiotropic effects leading to sta
Autor:
Soala Ikiriko, Damilare Rotimi, Abayomi Emmanuel Adegboyega, Oluwafemi Adeleke Ojo, Gaius Olorunfemi Akinyemi, Jane-Rose I. Oche, Jesuseyifunmi Ogunkua, Titilayo Omolara Johnson
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101175-(2021)
Acetylcholinesterase (AChE) has been an effective target for insecticide development which is a very important aspect of the global fight against insect-borne diseases. The drastic reduction in the sensitivity of insects to AChE-targeting insecticide
Autor:
Hiroshi Yamada, Ryo Taiji, Shunji Tsutsui, Terumasa Nakatsuka, Naoko Nishio, Wataru Taniguchi, Manabu Yamanaka
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101130-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) is a drug known for its inhibitory effect on glutamatergic transmission and its anti-nociceptive and anti-allodynic effects in neuropathic pain rat models. Riluzole also has an enhancing effect on
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101121-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Rutaecarpine is reported as a potent inducer of CYP1A2 enzyme in rats. There are natural herbal supplements containing rutaecarpine that are designed to enhance the CYP1A2-dependent removal of caffeine from blood so that people can have coffee later
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101144-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Temozolomide (TMZ) is a widely used chemotherapeutic agent for malignant glioma. β-Elemene has been reported to have the ability of passing through the blood-brain barrier and reverse multidrug resistance. In the present study, transport of drugs th
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101125-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
SAW1 is required by the Rad1-Rad10 nuclease for efficient removal of 3′ non-homologous DNA ends (flaps) formed as intermediates during two modes of double-strand break repair in S. cerevisiae, single-strand annealing (SSA) and synthesis-dependent s
Autor:
Chieko Iwao, Yoshihiro Shidoji
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101176-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Geranylgeranoic acid (GGA) was developed as a preventative agent against second primary hepatoma, and was reported to induce cell death in human hepatoma cells via Toll-like receptor 4 (TLR4)-mediated pyroptosis. We recently reported that GGA is enzy
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101112-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
The widespread application of protein and peptide therapeutics is hampered by their poor stability, strong immunogenicity and short half-life. However, the existing protein modification technologies require the introduction of exogenous macromolecule
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101149-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Vascular endothelial function deteriorates with age and disease, and the production of vasodilator factors like nitric oxide (NO) decreases. The free amino acid l-citrulline increases vasodilation and blood flow through increased NO production. We ex
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101155-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
3′-phosphoadenosine 5′-phosphosulfate (PAPS) is synthesized in two steps by PAPS synthase (PAPSS). PAPSS is comprised of ATP sulfurylase (ATPS) and APS kinase (APSK) domain activities. ATPS combines inorganic sulfate with α-phosphoryl of ATP to