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pro vyhledávání: '"Thomas Tuschl"'
Publikováno v:
Biochemistry. 32:11658-11668
The three guanosines of the central core of a hammerhead ribozyme were replaced by 2-aminopurine ribonucleoside, xanthosine, isoguanosine, inosine, and deoxyguanosine. These analogues were incorporated by automated solid-phase synthesis, with the exc
Publikováno v:
Biochemistry. 35(47)
Conformational changes of the hammerhead ribozyme were examined by fluorescence changes of 2-aminopurine riboside incorporated either in the substrate or in the ribozyme. Fluorescence changes could be observed for both the substituted substrate and r
Publikováno v:
Biochemistry. 33(40)
Isoguanosine has been incorporated into a 34-mer hammerhead ribozyme by the solid-phase phosphoramidite method, using an acetamidine base protecting group. The activity of the hammerhead ribozyme when singly mutated to isoguanosine at the adenosine p
Publikováno v:
Biochemistry. 33:848-848