Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hiroshi Sugiyama"'
Publikováno v:
Biochemistry. 57(5)
The G-quadruplex (G4) is one type of higher-order structure of nucleic acids and is thought to play important roles in various biological events such as regulation of transcription and inhibition of DNA replication. Pyrrole-imidazole polyamides (PIPs
Publikováno v:
Biochemistry. 43:2682-2687
5-Formyluracil (fU) is a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation. Although this residue is a potentially mutagenic lesion and is removed by several base excision repair enzymes, it is unknown whether fU
Autor:
Kawanishi M, Shosuke Kawanishi, Hiroshi Sugiyama, Isao Saito, Strekowski L, Wilson Wd, Shinji Oikawa
Publikováno v:
BIOCHEMISTRY. 39(43):13210-13215
An important approach to improve chemotherapy of members of the bleomycin (BLM) family of antibiotics is to find compounds (amplifiers) that enhance the activity of BLM-mediated DNA cleavage and apoptosis. Using a DNA-sequencing technique and pulsed
Publikováno v:
Biochemistry. 36:9995-10005
Pepleomycin (PEP)1 is a metalloglycopeptide antitumor antibiotic that has improved pharmacological properties than does bleomycin (BLM). Both PEP and BLM bind to and degrade DNA in a sequence-selective manner. The binding interactions of HO2--Co(III)
Publikováno v:
Biochemistry; 2/6/2018, Vol. 57 Issue 5, p498-502, 5p
Publikováno v:
Biochemistry. 32(4)
Duocarmycin A, a novel antitumor antibiotic, has a reactive cyclopropane ring, which has been reported to alkylate adenine at the 3' end of sequences of three or more consecutive A or T in DNA [Boger, D. L., et al. (1990) J. Am. Chem. Soc. 112, 8961-
Autor:
Luis O. Rodriguez, Sidney M. Hecht, Cheng Xu, Guy M. Ehrenfeld, Natesan Murugesan, Hiroshi Sugiyama, Robert E. Kilkuskie, Li Ho Chang
Publikováno v:
Biochemistry. 24(21)
By the use of DNA, copolymers of defined nucleotide composition, and a synthetic dodecanucleotide having putative bleomycin cleavage sites in proximity to the 5'- and 3'-termini, the products formed concomitant with DNA strand scission have been isol
Autor:
J. H. Van Boom, G. A. Van Der Marel, Hiroshi Sugiyama, Natesan Murugesan, Cheng Xu, Sidney M. Hecht
Publikováno v:
Biochemistry. 27(1)
Two sets of products are formed from DNA upon treatment with Fe(II).bleomycin + O2. One set, which is believed to derive from a C-4' hydroperoxy derivative of the DNA deoxyribose moiety, includes the four possible base propenals, as well as DNA oligo
Autor:
Hiroshi Sugiyama, Norman J. Oppenheimer, van Boom Jh, van der Marel Ga, Eric C. Long, Heimbrook Dc, Ehrenfeld Gm, Sidney M. Hecht, Joshua B. Shipley
Publikováno v:
Biochemistry. 26(3)
DNA strand scission by bleomycin in the presence of Cu and Fe was further characterized. It was found that DNA degradation occurred readily upon admixture of Cu(I) or Cu(II) + dithiothreitol + bleomycin, but only where the order of addition precluded