Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert C, James"'
Publikováno v:
Biochemical Pharmacology. 43:1989-1995
Cocaethylene is a novel metabolite of cocaine formed in the presence of ethanol. When administered to ICR male mice in dosages ranging from 10 to 50 mg/kg, i.p., cocaethylene was found to produce dose-dependent hepatic necrosis in the midlobular zone
Autor:
Raymond D. Harbison, Robert C. James
Publikováno v:
Biochemical Pharmacology. 31:1829-1835
Four compounds forming metabolic intermediate complexes with cytochrome P-450 in vitro were studied for their effects on hepatic glutathione in the mouse. All four compounds depleted glutathione within 1–3 hr after administration. The effect was tr
Publikováno v:
Biochemical Pharmacology. 30:993-999
The influence of carbon tetrachloride on several routes of drug metabolism has been investigated in the rat in vivo , in isolated perfused livers, and in hepatic microsomal preparations to evaluate the hypothesis that hepatic glucuronyl transferase a
Autor:
Michael R. Franklin, Robert C. James
Publikováno v:
Biochemical pharmacology. 24(8)
The formation of 455 nm complexes during the metabolism of various drugs has previously been studied in the rat. The formation of 455 nm complexes during the metabolism of amphetamine congeners and other compounds has now been studied in the rabbit t
Publikováno v:
Biochemical pharmacology. 36(18)
Morphine administration has been associated with a decrease in hepatic glutathione (GSH) and an increase in the hepatotoxicity of compounds dependent upon GSH for detoxification. In this study, intraperitoneal administration of 100 mg/kg morphine in