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Autor:
Corrado Garbazza, Georg Gruber, Sophia Rehm, Helen Slawik, Simon Veitz, Carolin Reichert, Katharina Rentsch, Martin Meyer, Yu-Shiuan Lin, Gunnar Deuring, Miriam Bühler, Janine Weibel
Publikováno v:
Biochemical Pharmacology. 191:114283
Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing sleep and circadian timing. In a 28-hour dou
Publikováno v:
Biochemical Pharmacology. 145:147-157
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is an enzyme with multiple functions in vertebrates. COMT methylates and thus inactivates catecholamine neurotransmitters and metabolizes xenobiotic catechols. Gene polymorphism rs4680 that influences t
Publikováno v:
Biochem Pharmacol
Among the more promising treatments proposed for Alzheimer’s disease (AD) and Parkinson’s disease (PD) are those reducing brain insulin resistance. The antidiabetics in the class of incretin receptor agonists (IRAs) reduce symptoms and brain path
Publikováno v:
Biochemical Pharmacology. 99:113-122
Our recent studies suggest that brain serotonergic system may be involved in the neuroendocrine regulation of cytochrome P450 expression. Intracerebral injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine affected serum hormone concentrat
Autor:
Corina Bejar, Priyashree Sunita, Marganit Cohen, Alina Nemirovski, Dinorah Barasch, Dorit Moradov, Efrat Finkin-Groner, Marta Weinstock, Donna Schorer-Apelbaum
Publikováno v:
Biochemical Pharmacology. 94:164-172
Ladostigil is a pseudo reversible inhibitor of acetylcholinesterase (AChE) that differs from other carbamates in that the maximal enzyme inhibition obtainable does not exceed 50-55%. This could explain the low incidence of cholinergic adverse effects
Autor:
Tamara Vasiljevik, William E. Fantegrossi, Thomas E. Prisinzano, Anna Gallus-Zawada, Paul L. Prather, Anna Radominska-Pandya, Jeffery H. Moran, Lisa K. Brents
Publikováno v:
Biochemical Pharmacology. 83:952-961
K2 and several similar purported “incense products” spiked with synthetic cannabinoids are abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent cannabinoid found in K2, contributes to toxicity associated with K2
Publikováno v:
Biochemical Pharmacology. 82:828-841
Nine nicotinic receptor subunits are expressed in the central nervous system indicating that a variety of nicotinic acetylcholine receptors (nAChR) may be assembled. A useful method with which to identify putative nAChR is radioligand binding. In the
Autor:
Brian H. Harvey, Jacobus P. Petzer, Christiaan B. Brink, Francois P. Viljoen, Gregers Wegener, Ingrid Duvenhage, Sarel F. Malan, Nellie Scheepers
Publikováno v:
Harvey, B H, Duvenhage, I, Viljoen, F, Scheepers, N, Malan, S F, Wegener, G, Brink, C B & Petzer, J P 2010, ' Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues ', Biochemical Pharmacology, vol. 80, no. 10, pp. 1580-91 . https://doi.org/10.1016/j.bcp.2010.07.037
Udgivelsesdato: 2010-Nov-15 Dual action antidepressants have important therapeutic implications. Methylene blue (MB), a charged compound structurally related to tricyclic antidepressants, acts on both monoamine oxidase (MAO) and the nitric oxide (NO)
Publikováno v:
Biochemical Pharmacology. 79:1791-1796
d-Serine, an endogenous co-agonist for the N-methyl-d-aspartate (NMDA) receptor in mammals, is synthesized from l-serine by serine racemase. Although much attention has been focused on the role of d-serine within the central nervous system, the physi
Autor:
Jens Halvard Grønlien, Monika Håkerud, Rachid El Kouhen, Clark A. Briggs, David J. Anderson, Murali Gopalakrishnan, Caroline Wetterstrand, John Malysz
Publikováno v:
Biochemical Pharmacology. 78:844-851
alpha4beta2 neuronal nicotinic receptors (nAChRs) can exist in high and low sensitivity states possibly due to distinct stoichiometries during subunit assembly: (alpha4)(2)(beta2)(3) pentamer (high sensitivity, HS) and (alpha4)(3)(beta2)(2) pentamer