Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Prasad A"'
Publikováno v:
Biochemical Journal. 476:1465-1482
Ubiquitin RING E3 ligases (E3s) catalyze ubiquitin (Ub) transfer to their substrates by engaging E2∼Ub intermediates with the help of their RING domains. Different E3s have been found to contain a conserved tryptophan residue in their RING that pla
Autor:
Adaitya Prasad Behera, Asim Poddar, Ajit B. Datta, Pritam Naskar, Prerana Agarwal Banka, Shubhangi Agarwal
Publikováno v:
Biochemical Journal
Biochem J
Biochem J
RING (Really Interesting New Gene) domains in ubiquitin RING E3 ligases exclusively engage ubiquitin (Ub)-loaded E2s to facilitate ubiquitination of their substrates. Despite such specificity, all RINGs characterized till date bind unloaded E2s with
Autor:
Adaitya Prasad Behera, Pritam Naskar, Shubhangi Agarwal, Prerana Agarwal Banka, Asim Poddar, Ajit B. Datta
Publikováno v:
Biochemical Journal. 476:2515-2516
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Yangzom D. Bhutia, Puttur D. Prasad, Sabarish Ramachandran, Jaya P. Gnana-Prakasam, Ellappan Babu
Publikováno v:
Biochemical Journal
The cancer-specific nutrient transporter, SLC6A14, could be a means to target cancer metabolism as described by Babu et al. in this issue.
Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to
Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to
Autor:
Puttur D. Prasad, Muthusamy Thangaraju, Nagendra Singh, Vadivel Ganapathy, Veena Coothankandaswamy, Selvakumar Elangovan
Publikováno v:
Biochemical Journal. 450:169-178
SLC5A8 (solute carrier gene family 5A, member 8) is a sodium-coupled transporter for monocarboxylates. Among its substrates are the HDAC (histone deacetylase) inhibitors butyrate, propionate and pyruvate. Expression of SLC5A8 is silenced in cancers v
Publikováno v:
Biochemical Journal. 445:313-322
A major multidrug transporter, MDR1 (multidrug resistance 1), a member of the MFS (major facilitator superfamily), invariably contributes to an increased efflux of commonly used azoles and thus corroborates their direct involvement in MDR in Candida
Publikováno v:
Biochemical Journal
The action of multidrug efflux pumps in MDR (multidrug resistance) acquisition has been proposed to partially depend on the transport of physiological substrates which may indirectly affect drug partition and transport across cell membranes. In the p
Publikováno v:
Biochemical Journal. 343:615-620
Ectopic expression of the basic helix-loop-helix transcription factor TAL1 (or SCL) is the most frequent gain-of-function mutation in T-cell acute lymphoblastic leukaemia. Gene-knockout studies in mice have demonstrated that TAL1 is required for embr
Autor:
Jayanta Roy Chowdhury, Sandra Hellwig, Conny T. Bakker, Kouji Tada, Piter J. Bosma, Vinayaka R. Prasad, Ronald P.J. Oude Elferink, Namita Roy Chowdhury, Jurgen Seppen
Publikováno v:
Scopus-Elsevier
Biochemical journal, 314 ( Pt 2), 477-483. Portland Press Ltd.
Biochemical journal, 314 ( Pt 2), 477-483. Portland Press Ltd.
Crigler–Najjar (CN) disease is an inherited disorder of bilirubin metabolism. The disease is caused by a deficiency of the hepatic enzyme bilirubin UDP-glucuronosyltransferase (B-UGT). Patients with CN disease have high serum levels of the toxic co
Autor:
Sreejesh Shanker, B. V. V. Prasad, C. S. Hill, Joydip Das, Noemi Kedei, Ghazi M. Rahman, Peter M. Blumberg, Nancy E. Lewin
Publikováno v:
Biochemical Journal. 453:153-153
PKC (protein kinase C) θ is predominantly expressed in T-cells and is critically involved in immunity. Design of PKCθ-selective molecules to manage autoimmune disorders by targeting its activator-binding C1 domain requires the knowledge of its stru