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Publikováno v:
Biochem J
Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented.
Publikováno v:
Biochemical Journal
The mechanism of generation of factor VIIa, considered the initiating protease in the tissue factor-initiated extrinsic limb of blood coagulation, is obscure. Decreased levels of plasma VIIa in individuals with congenital factor IX deficiency suggest
Publikováno v:
Biochemical Journal. 476:1419-1431
Phosphatase of regenerating liver (PRL) is overexpressed in metastatic cancers and actively drives their malignant progression. Many studies on cultured cancer cells have implied PRL overexpression as a stimulant for cellular signaling involved in ce
Autor:
Hans Jörnvall, Nikita A. Prokopev, Igor E. Kasheverov, Rustam H. Ziganshin, Ulrich Kuch, Lawan Chanhome, Victor I. Tsetlin, David A. Warrell, Dietrich Mebs, Gunvor Alvelius, Tomas Bergman, Dmitry S. Lebedev, Iakov Polyak, Ella Cederlund, Yuri N. Utkin, Igor Ivanov, Brian E. Molles
Publikováno v:
Biochemical Journal. 476:1285-1302
αδ-Bungarotoxins, a novel group of long-chain α-neurotoxins, manifest different affinity to two agonist/competitive antagonist binding sites of muscle-type nicotinic acetylcholine receptors, being more active at the interface of α-δ-subunits. Th
Autor:
Carrie A. Duckworth, Christopher E. Goldring, Parveen Sharma, B. Kevin Park, Stephen Lynch, Chris S. Pridgeon
Publikováno v:
The Biochemical journal
BIOCHEMICAL JOURNAL
BIOCHEMICAL JOURNAL
Adverse drug reactions (ADRs) are the unintended side effects of drugs. They are categorised as either predictable or unpredictable drug-induced injury and may be exhibited after a single or prolonged exposure to one or multiple compounds. Historical
Autor:
Han Liu, Zhaofeng Li, Suiyi Tan, Shuwen Liu, Wenjuan Li, Mengjie Qiu, Zichao Yang, Tao Qi, Xuefeng Zhou, Jinqing Li, Lin Li, Yurong Qiu, Tingting Zhang
Publikováno v:
Biochemical Journal. 476:1021-1035
Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, could remarkably enhance HIV-1 sexual transmission and thus are potential targets for the development of an effective microbicide. Pr
Autor:
Yoshinori Maeda, Daisuke Koga, Masahiro Hosaka, Hiroshi Gomi, Airi Hinata, Yui Sato, Seiji Torii, Tsuyoshi Watanabe, Eri Sato
Publikováno v:
Biochemical Journal. 476:827-842
To closely mimic physiological conditions, low oxygen cultures have been employed in stem cell and cancer research. Although in vivo oxygen concentrations in tissues are often much lower than ambient 21% O2 (ranging from 3.6 to 12.8% O2), most cell c
Publikováno v:
Biochemical Journal. 476:795-808
Antibiotic-resistant bacteria pose the greatest threat to human health. Among the list of such bacteria released by WHO, carbapenem-resistant Acinetobacter baumannii, for which almost no treatment exists, tops the list. A. baumannii is one of the mos
Autor:
Graham P. Holloway, Heather L. Petrick
Publikováno v:
Biochemical Journal. 476:547-558
The decline in fat oxidation at higher power outputs of exercise is a complex interaction between several mechanisms; however, the influence of mitochondrial bioenergetics in this process remains elusive. Therefore, using permeabilized muscle fibers
Autor:
Dieter Brömme, Xin Du, Preety Panwar, Michel Roberge, Simon Law, Tom A. Pfeifer, Nicolette S. Honson
Publikováno v:
Biochemical Journal. 476:499-512
Cathepsin K (CatK) is a cysteine protease and drug target for skeletal disorders that is known for its potent collagenase and elastase activity. The formation of oligomeric complexes of CatK in the presence of glycosaminoglycans has been associated w