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Autor:
Nagendra Singh, Punit Kaur, Juhi Sikarwar, Prashant Singh, Tej P. Singh, Naseer Iqbal, Sujata Sharma, Sanket Kaushik, Mohammad Owais, Pradeep Sharma
Publikováno v:
Biochemical Journal. 475:547-560
Peptidyl-tRNA hydrolase (Pth) catalyzes the breakdown of peptidyl-tRNA into peptide and tRNA components. Pth from Acinetobacter baumannii (AbPth) was cloned, expressed, purified and crystallized in a native unbound (AbPth-N) state and in a bound stat
Autor:
Rachel A. Powers, David A. Leonard, Robert A. Bonomo, Thomas M. Harper, Cynthia M. June, Magdalena A. Taracila
Publikováno v:
Biochemical Journal. 475:273-288
OXA-239 is a class D carbapenemase isolated from an Acinetobacter baumannii strain found in Mexico. This enzyme is a variant of OXA-23 with three amino acid substitutions in or near the active site. These substitutions cause OXA-239 to hydrolyze late
Publikováno v:
Biochemical Journal. 473:651-660
Leishmania major dihydro-orotate dehydrogenase (DHODHLm) has been considered as a potential therapeutic target against leishmaniasis. DHODHLm, a member of class 1A DHODH, oxidizes dihydro-orotate (DHO) to orotate (ORO) during pyrimidine biosynthesis
Publikováno v:
Biochemical Journal
Structural plasticity plays a major role in determining differential binding of CXCL8 monomer and dimer to glycosaminoglycans (GAGs) and that dimer is the high-affinity GAG ligand. We propose that these properties play important roles in orchestratin
Publikováno v:
Biochemical Journal. 460:447-457
It is known that the majority of cocaine users also consume alcohol. Alcohol can react with cocaine to produce a significantly more cytotoxic compound, cocaethylene. Hence a truly valuable cocaine-metabolizing enzyme as treatment for cocaine abuse/ov
Publikováno v:
Biochemical Journal. 454:303-310
To identify high-affinity interactions between long-chain α-neurotoxins and nicotinic receptors, we determined the crystal structure of the complex between α-btx (α-bungarotoxin) and a pentameric ligand-binding domain constructed from the human α
Autor:
Zrinka Kovarik, Trevor J. Dale, Božica Radić, Gabriel Amitai, Dariush Ajami, Julius Rebek, Suzana Berend, Zoran Radić, Edzna Garcia, Limin Zhang, Palmer Taylor, Carol E. Green, Brendan M. Duggan
Publikováno v:
Biochemical Journal. 450:231-242
In the present paper we show a comprehensive in vitro , ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide OPs (organophosphates) catalysed by purified hBChE (human butyrylcholinesterase) in combination with novel non
Autor:
Davide Gaudesi, Giangiacomo Torri, Marco Guerrini, Stefano Elli, Christian Boudier, Christian Viskov, Pierre Mourier, Benito Casu, Timothy R. Rudd
Publikováno v:
ResearcherID
The 3-O-sulfation of N-sulfated glucosamine is the last event in the biosynthesis of heparin/heparan sulfate, giving rise to the antithrombin-binding pentasaccharide sequence AGA*IA, which is largely associated with the antithrombotic activity of the
Publikováno v:
Biochemical Journal. 444:417-428
FH (Factor H) with 20 SCR (short complement regulator) domains is a major serum regulator of complement, and genetic defects in this are associated with inflammatory diseases. Heparan sulfate is a cell-surface glycosaminoglycan composed of sulfated S
Autor:
Yu-Nan Liu, Ping-Chiang Lyu, Min-Fang Shih, Chao-Sheng Cheng, Shang-Te Danny Hsu, Dian-Jiun Chen, Tien-Sheng Tseng
Publikováno v:
Biochemical Journal
Drosophila melanogaster crammer is a novel cathepsin inhibitor that is involved in LTM (long-term memory) formation. The mechanism by which the inhibitory activity is regulated remains unclear. In the present paper we have shown that the oligomeric s