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Autor:
Cynthia M. Ferrara, Samuel W. Cushman
Publikováno v:
Biochemical Journal. 343:571-577
Agents that activate the G-protein G(i) (e.g. adenosine) increase, and agents that activate G(s) [e.g. isoprenaline (isoproterenol)] decrease, steady-state insulin-stimulated glucose transport activity and cell-surface GLUT4 in isolated rat adipose c
Publikováno v:
Biochemical Journal. 342:275-280
Recent studies have suggested that glucose may activate insulin gene transcription through increases in intracellular Ca(2+) concentration, possibly acting via the release of stored insulin. We have investigated this question by dynamic photon-counti
Publikováno v:
Biochemical Journal. 329:197-201
This study investigated whether conditions known to alter the activity and phosphorylation state of the pyruvate dehydrogenase complex have specific effects on the levels of isoenzymes of pyruvate dehydrogenase kinase (PDK) in rat heart. Immunoblot a
Autor:
Ellen M. Koehler-Stec, A. Ian Simpson, K. McDonald Horne, Theresa Davies-Hill, J. Susan Vannucci, R. Lynn Sorbara
Publikováno v:
Biochemical Journal. 328:511-516
Platelets derive most of their energy from anaerobic glycolysis; during activation this requirement rises approx. 3-fold. To accommodate the high glucose flux, platelets express extremely high concentrations (155±18 pmol/mg of membrane protein) of t
Autor:
Jacques Pairault, Annie Quignard-Boulangé, Sylvie Hauguel-de Mouzon, Christine Charon, Khadija El Hadri, Bruno Fève
Publikováno v:
Biochemical Journal. 323:359-364
The beta3-adrenergic receptor (beta3-AR) exerts a central role in the transduction of catecholamine effects in white and brown adipose tissue (WAT and BAT). A recent report has documented that insulin strongly down-regulates beta3-AR expression and c
Autor:
Irith Reuters, Elke R. Gizewski, Herbert de Groot, Michael Kirsch, Herbert Diederichs, Ursula Rauen
Publikováno v:
Biochemical Journal. 322:693-699
Hypothermia, as used for organ preservation in transplantation medicine, is generally supposed to lead to an intracellular accumulation of sodium, and subsequently of chloride, via inhibition of the Na+/K+-ATPase. However, on studying the cellular so
Publikováno v:
Biochemical Journal. 322:223-228
1. The effects of the nitric oxide (NO) donor sodium nitroprusside (SNP) on the rates of glucose transport and utilization and its interaction with insulin were investigated in rat soleus muscle in vitro. SNP stimulated the rate of 2-deoxyglucose tra
Publikováno v:
Biochemical Journal. 320:283-292
An endopeptidase (designated RSIP, for root-starvation-induced protease) was purified to homogeneity from glucose-starved maize roots. The molecular mass of the enzyme was 59 kDa by SDS/PAGE under reducing conditions and 62 kDa by gel filtration on a
Publikováno v:
Biochemical Journal. 318:767-770
The relationships between the increase in blood ketone-body concentrations and several parameters that can potentially influence the rate of hepatic fatty acid oxidation were studied during progressive starvation (up to 24 h) in the rat in order to d
Autor:
Robert S. Schmidli, Beverly E. Faulkner-Jones, R. F. L. James, Henry J. DeAizpurua, Leonard C. Harrison
Publikováno v:
Biochemical Journal. 317:713-719
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease in which cytokines are thought to play an important role in beta-cell destruction and immune regulation. A major target of beta-cell autoimmunity in IDDM is the enzyme glutamate deca