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Autor:
Dieter Brömme, Xin Du, Preety Panwar, Michel Roberge, Simon Law, Tom A. Pfeifer, Nicolette S. Honson
Publikováno v:
Biochemical Journal. 476:499-512
Cathepsin K (CatK) is a cysteine protease and drug target for skeletal disorders that is known for its potent collagenase and elastase activity. The formation of oligomeric complexes of CatK in the presence of glycosaminoglycans has been associated w
Autor:
Milosz Ruszkowski
Publikováno v:
Biochemical Journal. 475:2681-2697
In the first committed step of histidine biosynthesis, adenosine 5′-triphosphate (ATP) and 5-phosphoribosyl-α1-pyrophosphate (PRPP), in the presence of ATP phosphoribosyltransferase (ATP-PRT, EC 2.4.2.17), yield phosphoribosyl-ATP. ATP-PRTs are su
Publikováno v:
Biochemical Journal. 473:4413-4426
Ornidazole of the 5-nitroimidazole drug family is used to treat protozoan and anaerobic bacterial infections via a mechanism that involves preactivation by reduction of the nitro group, and production of toxic derivatives and radicals. Metronidazole,
Autor:
Graham P. Holloway, Heather L. Petrick
Publikováno v:
Biochemical Journal. 475:1267-1269
The movement of lipids across mitochondrial membranes represents a rate-limiting step in fatty acid oxidation within the heart. A key regulatory point in this process is flux through carnitine palmitoyltransferase-I (CPT-I), an enzyme located on the
Publikováno v:
Biochemical Journal. 460:447-457
It is known that the majority of cocaine users also consume alcohol. Alcohol can react with cocaine to produce a significantly more cytotoxic compound, cocaethylene. Hence a truly valuable cocaine-metabolizing enzyme as treatment for cocaine abuse/ov
Publikováno v:
Biochemical Journal. 456:47-54
NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K. The enzyme may play a role in vitamin K metabolism by reducing vitamin K to
Autor:
Nick Todorovic, Alfredo Capretta, Tushar Shakya, Elena Evdokimova, Peter J. Stogios, Gerard D. Wright, Peter Spanogiannopoulos, Olga Egorova, Alexei Savchenko
Publikováno v:
Biochemical Journal. 454:191-200
Activity of the aminoglycoside phosphotransferase APH(3′)-Ia leads to resistance to aminoglycoside antibiotics in pathogenic Gram-negative bacteria, and contributes to the clinical obsolescence of this class of antibiotics. One strategy to rescue c
Autor:
Dennis J. Stuehr, Craig Hemann, Ashis Biswas, Zachary Novince, Mohammad Mahfuzul Haque, Douglas C. Goodwin, Cornelius L. Varnado, Russ Hille, Jesús Tejero, Zhi Qiang Wang
Publikováno v:
Biochemical Journal. 433:163-174
NOSs (NO synthases, EC 1.14.13.39) are haem-thiolate enzymes that catalyse a two-step oxidation of L-arginine to generate NO. The structural and electronic features that regulate their NO synthesis activity are incompletely understood. To investigate
Autor:
J. Mertens-Strijthagen, Simone Wattiaux-De Coninck, Michel Jadot, Jacqueline Thirion, Bruno Flamion, Robert Wattiaux, Marie-Christine Gasingirwa
Publikováno v:
Biochemical Journal
Biochemical Journal, Portland Press, 2010, 430 (2), pp.305-313. ⟨10.1042/BJ20100711⟩
Biochemical Journal, Portland Press, 2010, 430 (2), pp.305-313. ⟨10.1042/BJ20100711⟩
It has been suggested that intracellular Hyal-1 (hyaluronidase-1), which is considered a lysosomal enzyme, originates via endocytosis of the serum enzyme. To test this proposal we have investigated the uptake and intracellular distribution of rhHyal-
Autor:
Sanjit Dey, Churala Pal, Benu Brata Das, Venkatachalam S. Giri, Hemanta K. Majumder, Somdeb Bose Dasgupta, Amit Roy, Neeta V. M. Khalkho, Sumit Dey, Agneyo Ganguly, Parasuraman Jaisankar
Publikováno v:
Biochemical Journal. 409:611-622
DIM (3,3′-di-indolylmethane), an abundant dietary component of cruciferous vegetables, exhibits a wide spectrum of pharmacological properties. In the present study, we show that DIM is a potent inhibitor of Leishmania donovani topoisomerase I with