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Autor:
Lee Ann Johnston, Elaine Huston, Gino Van Heeke, Suat Erdogan, Rachael Barber, Martin J. Lynch, York Fong Cheung, Michael Sullivan, David R. Adams, Miles D. Houslay, George S. Baillie
Publikováno v:
Biochemical Journal. 380:371-384
PDE4A7 is an isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene that fails to hydrolyse cAMP and whose transcripts are widely expressed. Removal of either the N- or C-terminal unique portions of PDE4A7 did not reconstitute cataly
Publikováno v:
Biochemical Journal. 377:733-739
We postulated that adenosine function could be related to some of the neurological features of Lesch-Nyhan syndrome and therefore characterized adenosine transport in PBLs (peripheral blood lymphocytes) obtained from Lesch-Nyhan patients (PBL(LN)) an
Autor:
Scott A. Rivkees, Thomas B. Woolf, Timothy Othman, Henglin Yan, Dongcheng Lu, Christopher P. Turner
Publikováno v:
Biochemical Journal. 377:51-59
To identify binding partners of the A1AR (A1 adenosine receptor), yeast two-hybrid screening of a rat embryonic cDNA library was performed. This procedure led to the identification of erythrocyte membrane cytoskeletal protein (represented as 4.1G) as
Autor:
Taku Nedachi, Miyako Ariga, Shinichiro Takahashi, Fumihiko Hakuno, Hideki Sakamoto, Yoshiaki Ito, Masakazu Akahori
Publikováno v:
Biochemical Journal. 348:409-416
We have reported that pretreatment of rat FRTL-5 thyroid cells with thyrotropin (TSH) markedly potentiates the mitogenic response to insulin-like growth factor-I (IGF-I). The present study was undertaken to determine whether the augmentation by cAMP
Publikováno v:
Biochemical Journal. 330:1179-1187
The roles of a trimeric GTP-binding regulatory protein, protein kinase A and mitochondria in the regulation of store-activated (thapsigargin-stimulated) Ca2+ inflow in freshly-isolated rat hepatocytes were investigated. Rates of Ca2+ inflow were esti
Publikováno v:
Biochemical Journal. 330:701-706
In rats, the daily changes in hepatic lipase (HL) activity in the liver follow the diurnal rhythm of the catecholamines. To study the underlying mechanism, the effect of adrenaline on maturation and secretion of HL was determined in freshly isolated
Publikováno v:
Biochemical Journal. 328:689-694
Bradykinin stimulates cAMP synthesis in cultured airway smooth muscle (ASM) cells. This occurs via a pathway that involves: (1) the protein kinase C (PKC)-dependent activation of mitogen-activated protein kinase (MAPK); (2) the MAPK-dependent phospho
Autor:
Gideon Koren, J. Eduardo Folco
Publikováno v:
Biochemical Journal. 328:37-43
The inducible cAMP early repressor (ICER) is a powerful transcriptional inhibitor that plays an important role in the regulation of the cAMP-dependent transcriptional response in the neuroendocrine system. ICER activity is primarily determined by its
Autor:
Stefan R. Nahorski, Neil T. Burford
Publikováno v:
Biochemical Journal. 315:883-888
The mechanism underlying muscarinic m1 receptor-mediated increases in adenosine 3',5'-cyclic monophosphate (cAMP) was investigated in Chinese hamster ovary (CHO) cells expressing human recombinant m1 muscarinic receptors (CHO-ml cells). Stimulation o
Publikováno v:
Biochemical Journal. 314:555-561
Schwann cells play an important role in both the development and regeneration of peripheral nerves. Proliferation and differentiation of Schwann cells are critically dependent on changes in the levels of cAMP. ATP is a fast excitatory transmitter in