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Autor:
Philippe Gillet, Michel Malaise, Olivier Malaise, Céline Deroyer, Biserka Relic, Dominique de Seny, Zelda Plener
Publikováno v:
Biochemical Journal
Autophagy receptor p62/SQSTM1 signals a complex network that links autophagy-lysosomal system to proteasome. Phosphorylation of p62 on Serine 349 (P-Ser349 p62) is involved in a cell protective, antioxidant pathway. We have shown previously that P-Se
Publikováno v:
Biochemical Journal. 478:1435-1451
Rivastigmine is a clinical drug for patients of Alzheimer's disease (AD) exerting its inhibitory effect on acetylcholinesterase activity however, its effect on other disease-related pathological mechanisms are not yet known. This study was conducted
Autor:
Ziyang Fu, Zhihong Liu, Yingjie Wang, Jihui Li, Yuxin Ye, Jinle Tang, Jiali Gao, Dante Neculai, Manisha Talukdar, Hao Huang, Huan Zhou
Publikováno v:
Biochemical Journal. 477:3387-3399
The pseudokinase (PK) RNase L is a functional ribonuclease and plays important roles in human innate immunity. The ribonuclease activity of RNase L can be regulated by the kinase inhibitor sunitinib. The combined use of oncolytic virus and sunitinib
Autor:
Hampapathula Adimurthy Nagarajaram, Guruprasad Varma Konduru, Rajagopal Subramanyam, Ramurthy Gudla, Hari Parapatla, Dayananda Siddavattam, Elsin Raju Devadasu, Manjula Sritharan
Publikováno v:
Biochemical Journal. 477:2821-2840
Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct i
Publikováno v:
Biochem J
Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented.
Publikováno v:
Biochemical Journal
The mechanism of generation of factor VIIa, considered the initiating protease in the tissue factor-initiated extrinsic limb of blood coagulation, is obscure. Decreased levels of plasma VIIa in individuals with congenital factor IX deficiency suggest
Publikováno v:
Biochemical Journal. 476:1419-1431
Phosphatase of regenerating liver (PRL) is overexpressed in metastatic cancers and actively drives their malignant progression. Many studies on cultured cancer cells have implied PRL overexpression as a stimulant for cellular signaling involved in ce
Autor:
Graham P. Holloway, Heather L. Petrick
Publikováno v:
Biochemical Journal. 476:547-558
The decline in fat oxidation at higher power outputs of exercise is a complex interaction between several mechanisms; however, the influence of mitochondrial bioenergetics in this process remains elusive. Therefore, using permeabilized muscle fibers
Publikováno v:
Biochemical Journal. 475:2997-3008
The mechanisms regulating oxidative phosphorylation during exercise remain poorly defined; however, key mitochondrial proteins, including carnitine palmitoyltransferase-I (CPT-I) and adenine nucleotide translocase, have redox-sensitive sites. Interes
Autor:
Nagendra Singh, Punit Kaur, Juhi Sikarwar, Prashant Singh, Tej P. Singh, Naseer Iqbal, Sujata Sharma, Sanket Kaushik, Mohammad Owais, Pradeep Sharma
Publikováno v:
Biochemical Journal. 475:547-560
Peptidyl-tRNA hydrolase (Pth) catalyzes the breakdown of peptidyl-tRNA into peptide and tRNA components. Pth from Acinetobacter baumannii (AbPth) was cloned, expressed, purified and crystallized in a native unbound (AbPth-N) state and in a bound stat