Zobrazeno 1 - 10
of 72
pro vyhledávání: ''
Autor:
Laurent M. Arsac, Karine Nouette-Gaulain, Rodrigue Rossignol, Eric Thiaudière, Philippe Diolez, Veronique Deschodt-Arsac, Sylvain Miraux
Publikováno v:
Biochemical Journal. 444:315-321
Bupivacaine is a widely used anaesthetic injected locally in clinical practice for short-term neurotransmission blockade. However, persistent side effects on mitochondrial integrity have been demonstrated in muscle parts surrounding the injection sit
Autor:
Nadine Aurbek, Juan-Carlos Fontecilla-Camps, Florian Nachon, Horst Thiermann, Eugénie Carletti, Emilie Gillon, Yvain Nicolet, Patrick Masson, Franz Worek, Mélanie Loiodice
Publikováno v:
Biochemical Journal
Biochemical Journal, Portland Press, 2009, 421 (1), pp.97-106. ⟨10.1042/BJ20090091⟩
Biochemical Journal, Portland Press, 2009, 421 (1), pp.97-106. ⟨10.1042/BJ20090091⟩
hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). This bioscavenger is currently in Clinical Phase I for pretreatment of OP intoxication. Phosphylated ChEs (cholinesterases) can undergo a spontaneous time-dependen
Autor:
Gail Hilton, Ashwani Khanna, Jeannette Vasquez-Vivar, Vani Nilakantan, Galen M. Pieper, Nadine L. N. Halligan
Publikováno v:
Biochemical Journal. 391:541-547
Inducible nitric oxide synthase (iNOS) is a prominent component of the complex array of mediators in acute graft rejection. While NO production is determined by iNOS expression, BH4 (tetrahydrobiopterin), a cofactor of iNOS synthesized by GTP cyclohy
Autor:
Baljit Walia, Andrew T. Gewirtz, Shanthi V. Sitaraman, Jesse Roman, Lixin Wang, Florencia E. Castaneda, Vasantha L. Kolachala, Didier Merlin, Rahul Bajaj
Publikováno v:
Biochemical Journal. 382:589-596
Fibronectin (FN) is a multifunctional protein that plays important roles in many biological processes including cell adhesion and migration, wound healing and inflammation. Cellular FNs are produced by a wide variety of cell types including epithelia
Publikováno v:
Biochemical Journal. 379:587-593
Regulation of intracellular protein stability by the ubiquitin-dependent proteasome system plays a crucial role in cell function. HO-1 (haem oxygenase) is a stress response protein, which confers cytoprotection against oxidative injury and provides a
Publikováno v:
Biochemical Journal. 368:761-768
Malaria is one of the most devastating tropical diseases despite the availability of numerous drugs acting against the protozoan parasite Plasmodium in its human host. However, the development of drug resistance renders most of the existing drugs use
Autor:
Naila Ahmed, Paul J. Thornalley
Publikováno v:
Biochemical Journal. 364:15-24
Glycation of proteins leads to the formation of advanced glycation endproducts (AGEs) of diverse molecular structure and biological function. Serum albumin derivatives modified to minimal and high extents by methylglyoxal and glucose in vitro have be
Publikováno v:
Biochemical Journal. 364:211-218
NO is related to the pathological condition acute renal failure, in which we previously observed that the level of soluble dipeptidase in urine was decreased. In this study the role of NO in the shedding of the glycosylphosphatidylinositol (GPI)-anch
Publikováno v:
Biochemical Journal. 340:291-297
The oncoprotein Bcl-2 protects cells against apoptosis, but the exact molecular mechanism that underlies this function has not yet been identified. Studying H2O2-induced cell injury in Rat-1 fibroblast cells, we observed that Bcl-2 had a protective e
Publikováno v:
Scopus-Elsevier
A novel pterin intermediate, in addition to the expected 4a-hydroxytetrahydrobiopterin (4a-OH-BH4) and quinonoid dihydrobiopterin, was generated during catalytic turnover of tyrosine hydroxylase (TH) with tetrahydrobiopterin as the cofactor. Based on