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Publikováno v:
Biochemical Journal. 478:3977-3998
Tunneling nanotubes (TNTs) are F-actin-based, membrane-enclosed tubular connections between animal cells that transport a variety of cellular cargo. Over the last 15 years since their discovery, TNTs have come to be recognized as key players in norma
Publikováno v:
Biochemical Journal
The DAN (differential screening-selected gene aberrative in neuroblastoma) family are a group of secreted extracellular proteins which typically bind to and antagonize BMP (bone morphogenetic protein) ligands. Previous studies have revealed discrepan
Autor:
Han Liu, Zhaofeng Li, Suiyi Tan, Shuwen Liu, Wenjuan Li, Mengjie Qiu, Zichao Yang, Tao Qi, Xuefeng Zhou, Jinqing Li, Lin Li, Yurong Qiu, Tingting Zhang
Publikováno v:
Biochemical Journal. 476:1021-1035
Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, could remarkably enhance HIV-1 sexual transmission and thus are potential targets for the development of an effective microbicide. Pr
Autor:
Dong-Keun Song, Sung Joon Kim, Nam-Ho Kim, Chang-Won Hong, Joo Hyun Nam, Insuk So, Taek Keun Kim, Sung-Oh Huh, Jong-Ho Lee, Hwa Yong Ham, Won Gyun Ahn, Ju Suk Nam
Publikováno v:
Biochemical Journal. 455:319-327
TRPM2 (transient receptor potential melastatin 2) is a non-selective Ca2+-permeable cation channel activated by ADPR (adenosine diphosphoribose) and H2O2. It is widely expressed in mammalian cells and plays an important role in the regulation of vari
Autor:
Fabiana A. Carneiro, Miguel A. R. B. Castanho, Filomena A. Carvalho, Francisco Gomes-Neto, Fabio C. L. Almeida, Ronaldo Mohana-Borges, Andrea T. Da Poian, André F. Faustino, Nuno C. Santos, Ivo C. Martins, Patrícia T. Bozza
Publikováno v:
Biochemical Journal. 444:405-415
Dengue is the major arthropod-borne human viral disease, for which no vaccine or specific treatment is available. We used NMR, zeta potential measurements and atomic force microscopy to study the structural features of the interaction between dengue
Publikováno v:
Biochemical Journal. 443:635-642
The nonsense mutations R518X-KCNQ1 and Q530X-KCNQ1 cause LQT1 (long-QT syndrome type 1) and result in a complete loss of IKs channel function. In the present study we attempted to rescue the function of these mutants, in HEK (human embryonic kidney)-
Publikováno v:
Biochemical Journal. 428:183-190
H(2)DCF-DA (dihydrodichlorofluorescein diacetate) is widely used to evaluate 'cellular oxidative stress'. After passing through the plasma membrane, this lipophilic and non-fluorescent compound is de-esterified to a hydrophilic alcohol [H(2)DCF (dihy
Autor:
Tatiana V. Chepurnykh, Christopher S. Murphy, Dmitry Shcherbo, Elena A. Solovieva, Patrick M. Roche, Vladimir Z. Pletnev, Michael W. Davidson, Andrey G. Zaraisky, Vladislav V. Verkhusha, Aleksandr S. Shcheglov, Galina V. Ermakova, Dmitriy M. Chudakov, Sergey Lukyanov, Kristin L. Hazelwood
Publikováno v:
Biochemical Journal. 418:567-574
A vast colour palette of monomeric fluorescent proteins has been developed to investigate protein localization, motility and interactions. However, low brightness has remained a problem in far-red variants, which hampers multicolour labelling and who
Publikováno v:
Biochemical Journal. 382:557-564
Three CCD (central core disease) mutants, R4892W (Arg4892→Trp), I4897T and G4898E, in the pore region of the skeletal-muscle Ca2+-release channel RyR1 (ryanodine receptor 1) were characterized using a newly developed assay that monitored Ca2+ relea
Publikováno v:
Biochemical Journal. 331:331-339
TrpC1 appears to be a store-operated channel (SOC) when expressed in mammalian cells. In the present study, TrpC1 was expressed in Sf9 insect cells using the baculovirus expression system. Expression of TrpC1 caused an increase in basal cytosolic fre