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Publikováno v:
Biochemical Journal. 478:3905-3921
We have previously shown that the αvβ6 integrin plays a key role in promoting prostate cancer (PrCa) and it can be transferred to recipient cells via small extracellular vesicles (sEVs). Furthermore, we have reported in a proteomic analysis that α
Autor:
E. Dale Abel, Qian Shi, Biyi Chen, Jinxi Wang, Tianqing Peng, Long-Sheng Song, Grace Ciampa, Dong Zheng, Duane D. Hall
Publikováno v:
Biochemical Journal
Calpain proteolysis contributes to the pathogenesis of heart failure but the calpain isoforms responsible and their substrate specificities have not been rigorously defined. One substrate, Junctophilin-2 (JP2), is essential for maintaining junctional
Autor:
Partha Chakrabarti, Piyali Majumder, Kaushik Chanda, Nihar Ranjan Jana, Debajyoti Das, Brijesh Kumar Singh, Debashis Mukhopadhyay
Publikováno v:
Biochemical Journal
Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and RYK, both targets of the same micro RNA miR-1271, exhibit significant and consis
Autor:
Andrew J. O. Smith, Ram H. Nagaraj, Ko Uoon Park, I. Michael Wormstone, Mina B. Pantcheva, Mi-Hyun Nam, Joseph A. Brzezinski, James J. Galligan, Kristofer S. Fritz
Publikováno v:
Biochem J
Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens epithelial cells (LECs) in response to transforming growth factor β2 (TGFβ2) has been con
Autor:
Bikash Dangi, Victor G. Zgoda, Nikita E. Vavilov, Marc A. Maldonado, Nadezhda Y. Davydova, Dmitri R. Davydov
Publikováno v:
Biochem J
In this study, we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system, we used CYP2E1-enriched human liver microsomes (HLM) obtained by th
Publikováno v:
Biochemical Journal. 476:3565-3581
Glycero-lysophospholipids, such as lysophosphatidic acids and lysophosphatidylserine, are gathering attention, since specific receptors have been identified. Most of these compounds have been proposed to be bound to albumin, while their associations
Autor:
Peixiang Wang, Wyatt W. Yue, Or Kakhlon, Hanoch Senderowitz, Netaly Khazanov, Igor M. Ferreira, Leonardo J. Solmesky, Alexander Lossos, Miguel Weil, Berge A. Minassian
Publikováno v:
Biochemical Journal. 474:3403-3420
Glycogen storage disorders (GSDs) are caused by excessive accumulation of glycogen. Some GSDs [adult polyglucosan (PG) body disease (APBD), and Tarui and Lafora diseases] are caused by intracellular accumulation of insoluble inclusions, called PG bod
Autor:
Estelle Willems, Bernard Rogister, Nicolas Goffart, Arnaud Lombard, Matthias Dedobbeleer, Stephen Freeman
Publikováno v:
Biochemical Journal. 474:2903-2924
Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or mutations affecting these enzymes have been demonst
Autor:
Sergiy M. Nadtochiy, Kevin Welle, Xenia Schafer, Sina Ghaemmaghami, Joshua Munger, Jimmy Zhang, Paul S. Brookes, Yves T. Wang, Keith Nehrke
Publikováno v:
Biochemical Journal. 474:2829-2839
2-hydroxyglutarate (2-HG) is a hypoxic metabolite with potentially important epigenetic signaling roles. The mechanisms underlying 2-HG generation are poorly understood, but evidence suggests a potential regulatory role for the sirtuin family of lysi
Autor:
Ian R. Sweet, Benjamin J. Reed, Huiliang Zhang, Austin M. Rountree, Adam S. Neal, Kelly Kernan, William R. A. Osborne, Brian Van Yserloo, Wang Wang
Publikováno v:
Biochemical Journal. 473:4443-4456
A real-time method to measure intracellular hydrogen peroxide (H 2 O 2 ) would be very impactful in characterizing rapid changes that occur in physiologic and pathophysiologic states. Current methods do not provide the sensitivity, specificity and sp