Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Biochemical and Biophysical Research Communications. 199:714-719
The possible involvement of PKC in the regulation of heat shock genes expression was investigated with three isoquinolinesulfonamide derivatives (H-7, H-8, and HA1004) in DUT-145, MCF-7, and MCF-7/ADR cells. The drug was added 1 hr before and during
Publikováno v:
Biochemical and Biophysical Research Communications. 186:1121-1128
When cells were heated for 15 min at 45 degrees C, they became thermotolerant to a second heat exposure at 45 degrees C. Thermotolerance developed rapidly, reached its maximum 6 hr after heat shock, and then gradually decayed. The development of ther
Publikováno v:
Biochemical and Biophysical Research Communications. 177:575-581
Protein denaturation resulting from temperatures between 42.0 degrees C and 50 degrees C has been observed and implicated as the lethal lesion for hyperthermic cell killing. A logical corollary is that protection against hyperthermic killing requires
Publikováno v:
Biochemical and Biophysical Research Communications. 172:119-125
We observed that members of two HSP families (70 and 28 kDa) preferentially redistributed into the nucleus after heating at 45.5 degrees C for 10 min. The rates of synthesis and redistribution of these proteins were different for each member of HSP f
Publikováno v:
Biochemical and biophysical research communications. 197(2)
We investigated the effects of combined treatment with homoharringtonine (HHT) and hyperthermia on cytotoxicity and transcriptional regulation of heat shock genes in human colon carcinoma (HT-29) cells. The drug (100 ng/ml) which inhibited protein sy
Publikováno v:
Biochemical and biophysical research communications. 176(3)
To investigate the possibility that nascent polypeptides released from polysomes by heat shock accumulate in the nucleus, cells were pulse labeled with [35S]methionine for two minutes and heated immediately thereafter at 45.5°C for 10 minutes. When
Publikováno v:
Biochemical and biophysical research communications. 157(2)
The mechanism by which Cycloheximide (CHM) protects cells from heat induced killing has been investigated. Cycloheximide (10 micrograms/ml) added for 2 hr before and during a 3 hour heating at 43 degrees C prevented a 40% increase of heat-induced pro