Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Peter J Tummino"'
Publikováno v:
Biochemical and Biophysical Research Communications. 201:290-294
The oral anticoagulant warfarin (4-hydroxy-3-(3-oxo-1-phenylbutyl)-benzopyran-2-one) is a structurally novel low micromolar competitive inhibitor of HIV-1 protease in vitro. It was recently reported that warfarin inhibits HIV-1 infection in U-1 monoc
Autor:
Kimberly Suzanne Para, Elizabeth A. Lunney, Eric L. Reyner, Stephen J. Gracheck, Andrea Heldsinger, Steve Vander Roest, Robert J. Guttendorf, John M. Domagala, Barbra H. Stewart, J. V. N. Vara Prasad, James Saunders, Donna Ferguson, Thomas J. McQuade, Peter J. Tummino
Publikováno v:
Biochemical and biophysical research communications. 221(3)
A systematic study of tethering various groups on 6-phenyl ring of 4-hydroxy-6-phenyl-3-[(2-iso-propylphenyl)thio]pyran-2-one was performed to increase the binding affinity with HIV protease. This tethering approach was aimed to fill S 3 pocket of th
Publikováno v:
Biochemical and biophysical research communications. 200(3)
The nonpeptide compounds C1 (4-hydroxy-3-(3-phenoxypropyl)-1-benzopyran-2-one) and P1 (4-hydroxy-6-phenyl-3-(phenylthio)-pyran-2-one) are structurally novel low micromolar inhibitors of the protease of human immunodeficiency virus type 1 (HIV-1). Kin