Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Herbert J. Zeh, Ulka Sachdev, Sebastian Vogel, Xiangdong Cui, Pranav Murthy, Michael T. Lotze
Publikováno v:
Biochemical and Biophysical Research Communications. 508:614-619
Platelets play a critical role in the pathophysiology of peripheral arterial disease (PAD). The mechanisms by which muscle ischemia regulates aggregation of platelets are poorly understood. We have recently identified the Nod-like receptor nucleotide
Publikováno v:
Biochemical and Biophysical Research Communications. 506:278-283
Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme derived from Streptococcus that has been widely used for genome editing in a variety of organisms, including humans. Here, we report that exogenous Cas9 protein can elicit an
Publikováno v:
Biochemical and Biophysical Research Communications. 458:650-655
High mobility group box 1 (HMGB1), histone, and DNA are essential nuclear components involved in the regulation of chromosome structure and function. In addition to their nuclear function, these molecules act as damage-associated molecular patterns (
Autor:
Sebastian Vogel, Ulka Sachdev, Xiao Liu, Alexander N.R. Weber, Jennifer L. Miller-Ocuin, Michael T. Lotze, Pranav Murthy, Xiangdong Cui, Meinrad Gawaz, Herbert J. Zeh, Xiaoyan Liang, Teiko Takedai, Shruthi Shankar, Dominik Rath, Filip Durco
Publikováno v:
Biochemical and biophysical research communications. 483(1)
Cleavage of interleukin-1β (IL-1β) is a key inflammatory event in immune cells and platelets, which is mediated by nucleotide-binding domain leucine rich repeat containing protein (NLRP3)-dependent activation of caspase-1. In immune cells, NLRP3 an
Autor:
Herbert J. Zeh, Yangchun Xie, Rui Kang, Daolin Tang, Xiaofang Sun, Michael T. Lotze, Jin Huang, Xinxin Song, Meizuo Zhong
Publikováno v:
Biochemical and biophysical research communications. 473(4)
Ferroptosis, a novel form of regulated cell death, is characterized by oxidative injury from iron accumulation and lipid peroxidation. In a natural product library screening for ferroptosis inhibitor, we found that baicalein is a potent inhibitor of