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Publikováno v:
Biochemical and Biophysical Research Communications. 424:251-256
Latent Epstein-Barr virus (EBV) infection is associated with human B cell lymphomas and certain carcinomas. EBV episome persistence, replication, and gene expression are dependent on EBV-encoded nuclear antigen 1 (EBNA1)’s DNA binding domain (DBD)/
Autor:
Chi-Ping Cheng, Ling-Chih Chen, Jia-Shih Fang, Bo Zhao, Chih-Wen Peng, Cheng-Der Liu, Elliott Kieff
Publikováno v:
Biochemical and biophysical research communications. 430(3)
Epstein–Barr Virus Nuclear Antigen (EBNA) 2 features an Arginine–Glycine repeat (RG) domain at amino acid positions 335–360, which is a known target for protein arginine methyltransferaser 5 (PRMT5). In this study, we performed protein affinity