Zobrazeno 1 - 10
of 9 880
pro vyhledávání: '"0301 basic medicine"'
Autor:
Ya-Yu Zhao, Chen-Chun Wang, Jia-Lu Ying, Xue Chen, Hong-Bo Jin, Cheng-Cheng Yang, Xin-Yao Yin, Yi-Chi Lu, Pan Du
Publikováno v:
Biochemical and Biophysical Research Communications. 568:103-109
At present, stem cell transplantation has a significant therapeutic effect on spinal cord injury (SCI), however, it is still challenging for the seed cells selection. In this study, in order to explore cells with wide neural repair potentials, we sel
Publikováno v:
Biochemical and Biophysical Research Communications. 568:76-82
Medulloblastoma, the most common malignant brain tumor in children, consists of four molecular subgroups WNT, SHH, Group 3, and Group 4. Group 3 has the worst survival rate among the four subgroups and is characterized by the expression of retina-spe
Autor:
Masayuki Kurimoto, Akane Hara, Yasuhiro Masuta, Tomohiro Watanabe, Ken Kamata, Tomoe Yoshikawa, Kosuke Minaga, Ryutaro Takada, Yasuo Otsuka, Ikue Sekai, Masatoshi Kudo
Publikováno v:
Biochemical and Biophysical Research Communications. 568:55-61
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular receptor for muramyl dipeptide derived from the intestinal microbiota. Loss-of-function mutations in Nod2 are associated with the development of Crohn's disease, suggesting that N
Publikováno v:
Biochemical and Biophysical Research Communications. 569:17-22
The pathogenesis of Parkinson's disease (PD) remains elusive, but mitochondrial dysfunction is believed to be one crucial step in its pathogenesis. The mitochondrial unfolded protein response (UPRmt) is an important mitochondrial quality control stra
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Autor:
Yasufumi Umena, Koji Inaka, Naoki Furubayashi, Masayuki Kamo, Takeshi Matsuoka, Yukio Morimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 568:131-135
The crystal structure of l -lactate oxidase in complex with l -lactate was solved at a 1.33 A resolution. The electron density of the bound l -lactate was clearly shown and comparisons of the free form and substrate bound complexes demonstrated that
Autor:
Xiao Xiao Lily Chen, Justin You, Jihye Rachel Kim, Rebekah van Bruggen, Ching Serena Kao, Hyeok Jun Lee, Mashiat Khan, David Duc Tran, Wooin Cho, Katarina Maksimovic, Jeehye Park
Publikováno v:
Biochemical and Biophysical Research Communications. 568:48-54
The F115C mutation in the MATR3 gene has been linked to amyotrophic lateral sclerosis (ALS). To determine the pathogenicity of the F115C mutation and the mechanism by which this mutation causes ALS, we generated mice that harbor the F115C mutation in
Publikováno v:
Biochemical and Biophysical Research Communications. 568:89-94
Manganese (Mn), even though an essential trace element, causes neurotoxicity in excess. In adults, over-exposure to Mn causes clinical manifestations, including dystonia, progressive bradykinesia, disturbance of gait, slurring, and stuttering of spee
Autor:
Hiroko Yamashita, Mira Suzuki, Akinori Yamauchi, Masaki Nagane, Kazuhiro Kato, Naoyuki Aihara, Shokichi Naito, Takuto Shimizu, Junichi Kamiie, Tadashi Yamashita, Nagako Kawashima
Publikováno v:
Biochemical and Biophysical Research Communications. 569:10-16
Cancer cells require oxygen and nutrients for growth, making angiogenesis one of the essential components of tumor growth. Gangliosides, constituting membrane lipid rafts, regulate intracellular signal transduction and are involved in the malignancy
Publikováno v:
Biochemical and Biophysical Research Communications. 568:15-22
Fibroblast migration is closely regulated by the mechanical characteristics in surrounding microenvironment. While increased interstitial hydrostatic pressure (HP) is a hallmark in many pathological and physiological conditions, little is known about