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Publikováno v:
Biochemical and Biophysical Research Communications. 553:1-8
Background and aims Hypercholesterolemia is characterized by the elevation of plasma total cholesterol level, especially low-density lipoprotein (LDL) cholesterol. This disease is usually caused by a mutation in genes such as LDL receptor, apolipopro
Autor:
Xinrui Zhao, Yuexin Jin, Zhongmin Tian, Yanan Ouyang, Xuewei Zheng, Pengfei Yang, Lan Chen, Li Zeng, Meng Chen
Publikováno v:
Biochemical and Biophysical Research Communications. 533:188-194
Aims Dahl salt-sensitive (SS) rats develop similar prediabetes lesion characteristics, such as impaired glucose tolerance (IGT), when compared with the salt resistant rat. In this study, we evaluate the risk of high glucose intake during prediabetes
Publikováno v:
Biochemical and Biophysical Research Communications. 529:425-431
Background: Loss of a-crystallin chaperone function results in the lens protein aggregation leading to cataract. In this study, we evaluated the efficacy of micellar lutein with different fatty acids in modulating a-crystallin chaperone function unde
Autor:
Yajun Duan, Jialing Ma, Jiamin Su, Yali Yan, Lipei Liu, Jihong Han, Xiaoxiao Yang, Miao Yu, Peng Zeng, Jie Yang, Wenquan Hu, Yuanli Chen
Publikováno v:
Biochemical and Biophysical Research Communications. 524:439-445
Calorie restriction (CR) ameliorates various diseases including cardiovascular disease. However, its protection and underlying mechanisms against atherosclerosis remain un-fully elucidated. In this study, we fed apoE deficient (apoE-/-) mice in Contr
Publikováno v:
Biochemical and Biophysical Research Communications. 523:315-321
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disease for which specific biomarkers and pathological mechanisms have yet to be identified. Methylphenidate (MPH) is commonly used to treat ADHD, but its therapeutic mechanisms
Autor:
Masaharu Kataoka, Keiichi Fukuda, Yoshinori Katsumata, Tomohiro Matsuhashi, Shinichi Goto, Hidenori Moriyama, Naohiro Yoshida, Sarasa Isobe, Fumiko Mitani, Kentaro Ito, Hiroki Kitakata, Nobuhito Goda, Tsunehisa Yamamoto, Jin Endo, Kaoru Yamashita, Kohsuke Shirakawa, Atsuhiro Ichihara, Motoaki Sano
Publikováno v:
Biochemical and Biophysical Research Communications. 524:184-189
Plasma aldosterone concentration increases in proportion to the severity of heart failure, even during treatment with renin-angiotensin system inhibitors. This study investigated alternative regulatory mechanisms of aldosterone production that are si
Autor:
Miaomiao Fan, Shan Wang, Tao Yin, Xiong Wang, Wenjun Yan, Ling Zhang, Yi Liu, Huishou Zhao, Congye Li, Ling Tao
Publikováno v:
Biochemical and Biophysical Research Communications. 516:1103-1109
Atherosclerosis is characterized by the accumulation of excess cholesterol in plaques. Reverse cholesterol transport (RCT) plays a key role in the removal of cholesterol. In the present study, we examined the effect of thioredoxin-1 (Trx-1) on RCT an
Publikováno v:
Biochemical and Biophysical Research Communications. 516:812-818
Proteinuria is an important marker and is closely related to the progressive decline of renal function. Our previous research showed that angiopoietin-like-3 (ANGPTL3) plays a crucial role in proteinuria. In this study, we prepared an antibody agains
Autor:
Eun-Woo Lee, Tae-Yong Kim, Chan-Hee Kim, Hyun-Tai Lee, Jung-ha Park, Shin-Kwon Kim, Chae Eun Kim, Won Je Jang, Mi-Hyeon Jeon, Su-Jeong Lee, Jong Min Lee
Publikováno v:
Biochemical and biophysical research communications. 571
This study investigated the properties of Latilactobacillus curvatus MS2 isolated from Korean traditional fermented seafood as probiotics and the effect of reducing cholesterol as a synbiotic with isomalto-oligosaccharide (IMO) in BALB/c mice. The is
Publikováno v:
Biochemical and biophysical research communications. 572
Previous study documented that Lactobacillus paracasei S0940 and Streptococcus thermophilus ldbm1 have obvious cholesterol-lowering abilities in vitro. In this study, the safety of two strains were evaluated by nitroreductase test, hemolysis test and