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Publikováno v:
Biochemical and Biophysical Research Communications. 584:60-65
Current study is intended to evaluate the expression and epigenetic variations of mitochondrial situins in 306 rheumatoid arthritis (RA) cases and compared with age/gender matched controls.The expression level was measured using the quantitative Real
Publikováno v:
Biochemical and Biophysical Research Communications. 576:73-79
Objectives MicroRNA-199b-3p (miR-199b-3p) plays a crucial role in the malignant development of various cancers, but little known in prostate cancer (PCa). The aim of our study was to demonstrate the function of miR-199b-3p in PCa. Methods Quantitativ
Publikováno v:
Biochemical and Biophysical Research Communications. 553:1-8
Background and aims Hypercholesterolemia is characterized by the elevation of plasma total cholesterol level, especially low-density lipoprotein (LDL) cholesterol. This disease is usually caused by a mutation in genes such as LDL receptor, apolipopro
Publikováno v:
Biochemical and Biophysical Research Communications. 555:46-53
The onset and progression of intervertebral disc degeneration (IVDD) is strictly associated with oxidative stress. TRIM21 (Tripartite motif-containing protein 21), a ubiquitin E3 ligase, has been shown to play an essential role in liver redox homeost
Publikováno v:
Biochemical and Biophysical Research Communications. 541:63-69
Background Decellularized adipose tissue (DAT) has attracted much attention due to its wide range of sources and adipose regeneration capacity. However, the lipogenic efficiency of DAT is still controversial due to its unclear mechanism. To this poin
Publikováno v:
Biochemical and Biophysical Research Communications. 534:99-106
Interstitial pneumonia with autoimmune features (IPAF) is an unexplained disease state characterized by autoimmunity and pulmonary fibrosis. Exploring the pathogenesis of IPAF is helpful for the treatment of interstitial pneumonia and idiopathic pulm
Publikováno v:
Biochemical and Biophysical Research Communications. 530:624-631
Long noncoding RNAs (lncRNAs) have been identified to be critical regulator for various human diseases and emerging evidence illustrate the essential function of lncRNAs in the non-small cell lung cancer (NSCLC). Here, our research team tried to iden
Publikováno v:
Biochemical and Biophysical Research Communications. 531:480-489
Currently, more and more studies show that aberrantly expressed microRNAs (miRNAs) are important driving factors for the pathogenesis of hepatocellular carcinoma (HCC). Based on the TCGA and GEO databases, miR-660-5p was identified as a possible targ
Autor:
Iwao Sekigawa, Takuya Hirai, Kenji Takamori, Yoshifumi Watanabe, Hiroshi Tsushima, Keigo Ikeda, Mitsutoshi Tominaga, Yasushi Suga, Yuko Yoshida, Shinji Morimoto, Kunihiro Hayakawa, Mikiko Kawasaki, Maki Fujishiro
Publikováno v:
Biochemical and Biophysical Research Communications. 529:1073-1079
DNA methylation is an epigenetic modification that regulates gene transcription. DNA methyltransferase 1 (DNMT1) plays an important role in DNA methylation. However, the involvement of DNMT1 and DNA methylation in the pathogenesis of atopic dermatiti
Publikováno v:
Biochemical and Biophysical Research Communications. 528:179-185
Sirt1 involved in cellular aging and aging-related diseases, including osteoarthritis (OA). Our previous study showed Sirt1 played a role in the pathogenesis of OA, however, the underlying mechanisms are still poorly elicited. In this study, we inves