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Publikováno v:
Biochemical and Biophysical Research Communications
SARS-CoV-2 first emerged in the human population in late 2019 in Wuhan, China, and in a matter of months, spread across the globe resulting in the Coronavirus Disease 19 (COVID-19) pandemic and substantial economic fallout. SARS-CoV-2 is transmitted
Publikováno v:
Biochemical and Biophysical Research Communications. 495:519-525
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that regulate immune responses in cancer and various pathological conditions. However, the phenotypic and functional heterogeneity of human MDSCs represents a major hurd
Autor:
Kosuke Odaira, Takuya Takahashi, Kazuhiro Kakimi, Nao Fujieda, Hirokazu Matsushita, Shin-nosuke Kimura, Kaori Kambara, Yukari Kobayashi, Izumi T
Publikováno v:
Biochemical and Biophysical Research Communications. 478:1298-1303
In addition to the majority of T cells which carry the αβ T cell receptor (TCR) for antigen, a distinct subset of about 1-5% of human peripheral blood T cells expressing the γδ TCR contributes to immune responses to infection, tissue damage and c
Autor:
Akira Nishio, Tomohide Tatsumi, Takeshi Takahashi, Yoshiki Onishi, Satoshi Aono, Takahiro Kodama, Seiichi Tawara, Ryotaro Sakamori, Minoru Shigekawa, Keisuke Fukutomi, Teppei Yoshioka, Hiroshi Suemizu, Tetsuo Takehara, Tasuku Nakabori, Hayato Hikita
Publikováno v:
Biochemical and biophysical research communications. 503(3)
It is well known that immune-mediated virus elimination is necessary for the treatment of HBV infection. Reconstitution of human immune cells in liver chimeric mice is warranted to understand the immunopathogenesis of HBV infection. Here, we report a
Publikováno v:
Biochemical and biophysical research communications. 488(1)
C-C chemokine receptor type 4 has been reported to correlate with lung cancer. However, the role of CCR4 in human non-small cell lung cancer patients is not well defined. Here, we demonstrated that increased expression of CCR4 was associated with cli
Autor:
Yan-Fei Wen, Ru Ding, Hui-Yan Lei, Zhihua Gong, Xiao-Long Gu, Ding-Cheng Xiang, Jian Qiu, Zheng-Hua Dong, Lan Ma, Na Ma, Jun Huang
Publikováno v:
Biochemical and Biophysical Research Communications. 443:932-937
Stromal cell-derived factor-1 (SDF-1) plays critical roles in vascular development and hematopoiesis. Here, we investigated the function of SDF-1 rs1801157G/A polymorphism in various immune cells and examined its association with susceptibility to co
Autor:
Sook-Bin Woo, Alessandro Villa, Hajime Sasaki, Jae Young Kim, Kenji Egashira, Tomomi Kiyama, Alexandru Movila, Toshihisa Kawai, Hani Mawardi, Kazuaki Nishimura
Publikováno v:
Biochemical and biophysical research communications. 480(1)
Prior consensus held that medication-related osteonecrosis of the jaw (MRONJ) lesion was composed of necrotic bone; however, more recent studies have identified inflammatory infiltrates in the lesion. Herein, we report that remarkably elevated infilt
Publikováno v:
Biochemical and biophysical research communications. 471(4)
Despite the introduction of new and effective immunosuppressive drugs, acute cellular graft rejection is still a major risk for graft survival. Modulating the dosage of immunosuppressive drugs is not a good choice for all patients, new rejection mech
Publikováno v:
Biochemical and Biophysical Research Communications. 407:599-604
Prevention of graft rejection in renal transplant recipients depends on chronic treatment with immunosuppressive agents. However, impaired immune functions and immunosurveillance may cause infection, cancer and many other problems, which subsequently
Autor:
Rinpei Morita, Takashi Shichita, Eiichi Hasegawa, Hideyuki Yoshida, Akihiko Yoshimura, Fumie Konoeda, Go Muto, Yuki Sugiyama, Norihiro Suzuki
Publikováno v:
Biochemical and Biophysical Research Communications. 402:500-506
Recently, T cell cytokines such as IL-17 and IFN-γ have been shown to play important roles in the progression of brain injury induced by ischemia. We have shown that IL-23 from infiltrated macrophages activates γδT cells, thereby inducing IL-17 fr