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Publikováno v:
Biochemical and Biophysical Research Communications. 580:1-6
Sphingosine kinase 2 (SphK2) inhibitors are developed for tumor therapy as considering its anti-tumor effect. Many studies also explored SphK2 modulated glucose and lipid homeostasis, which extended its potential function for metabolic diseases thera
Publikováno v:
Biochemical and Biophysical Research Communications. 545:1-7
Mammary epithelial cells synthesize and secrete norepinephrine (NE) into breast milk to regulate β-casein expression through the adrenergic β2 receptor. We investigated the expression, localization, and roles of NE transporter (NET) in the mammary
Autor:
Michiko Yanagisawa, Kazuhiko Namekata, Tomomi Aida, Sayaka Katou, Takuya Takeda, Takayuki Harada, Nobuo Fuse, null the Glaucoma Gene Research Group, Kohichi Tanaka
Publikováno v:
Biochemical and Biophysical Research Communications. 529:943-949
Glaucoma is one of the leading causes of blindness characterized by progressive loss of retinal ganglion cells (RGCs) and their axons. We reported that glutamate/aspartate transporter (GLAST) knockout mice showed progressive RGC loss and optic nerve
Autor:
Toshihiko Machiguchi, Tatsuo Nakamura
Publikováno v:
Biochemical and Biophysical Research Communications. 530:541-546
Kidney regeneration could be classified into 2 groups: kidney generation and kidney repair. We have attempted in vivo nephron generation for kidney repair, as a therapy for chronic renal failure (CRF), by exploiting cellular interactions via conditio
Autor:
Abdollah Amini, Pejman Kiani, Mohammad-Amin Abdollahifar, Mohsen Norouzian, Armin Khosravipour, Rouhallah Gazor, Mohammad Bayat, Fatemehsadat Rezaei, Seyed Kamran Ghoreishi, Michael R. Hamblin, Mehrdad Asgari, Fatemeh Fadaei Fathabady, Rahimeh B. Atashgah, Fatemeh Zare, Sufan Chien
Publikováno v:
Biochemical and Biophysical Research Communications. 530:173-180
We investigated the impact of human demineralized bone matrix (hDBM) plus adipose-derived stem cells (hADS) plus photobiomodulation (PBM) on a critical-sized femoral defect (CSFD) in ovariectomy induced osteoporosis in rats. There were 6 groups as fo
Autor:
Emiko Sato, Yuji Oe, Daisuke Saigusa, Hiroshi Sato, Ritsumi Saito, Sadayoshi Ito, Yoshiko Kawana, Akiyo Sekimoto, Nobuyuki Takahashi, Manami Kaneko, Yukako Tsunokuni, Shuichi Shimma
Publikováno v:
Biochemical and Biophysical Research Communications. 527:1064-1071
Preeclampsia (PE) is a leading cause of maternal morbidity and mortality. Nicotinamide has beneficial effects on PE. In this study, we evaluated the effect of nicotinamide on placental development using a PE mouse model. To generate the PE model, a r
Autor:
Shin Ichi Sueta, Yuko Katakai, Kenji Osafune, Naohide Ageyama, Takafumi Toyohara, Katsutaro Yasuda, Shinji Uemoto, Maki Kotaka
Publikováno v:
Biochemical and Biophysical Research Communications. 526:661-669
Orthotopic liver transplantation (OLT) is the only curative treatment for refractory chronic liver failure in liver cirrhosis. However, the supply of donated livers does not meet the demand for OLT due to donor organ shortage. Cell therapy using hepa
Autor:
Masaharu Kataoka, Keiichi Fukuda, Yoshinori Katsumata, Tomohiro Matsuhashi, Shinichi Goto, Hidenori Moriyama, Naohiro Yoshida, Sarasa Isobe, Fumiko Mitani, Kentaro Ito, Hiroki Kitakata, Nobuhito Goda, Tsunehisa Yamamoto, Jin Endo, Kaoru Yamashita, Kohsuke Shirakawa, Atsuhiro Ichihara, Motoaki Sano
Publikováno v:
Biochemical and Biophysical Research Communications. 524:184-189
Plasma aldosterone concentration increases in proportion to the severity of heart failure, even during treatment with renin-angiotensin system inhibitors. This study investigated alternative regulatory mechanisms of aldosterone production that are si
Publikováno v:
Biochemical and Biophysical Research Communications. 520:166-170
Raised brain levels of testosterone (Tes), as well as single nucleotide polymorphisms of P-glycoprotein (P-gp) that cause impaired transport function, are associated with increased risk of suicide. Here, we examined whether Tes and its precursors and
Publikováno v:
Biochemical and biophysical research communications. 558
Myocardial ischemia/reperfusion (I/R) injury is a major determinant of morbidity and mortality in patients undergoing treatment for cardiac disease. A variety of treatments are reported to have benefits against reperfusion injury, yet their cardiopro